Is Flmodafinil the Future of Nootropics? A Research-Based Guide

Flmodafinil, also known as CRL-40,940, NLS-4, and bisfluoromodafinil, is studied in several circles for its role in enhancing cognitive function and alertness. Being similar to modafinil, it has been examined for different neurological problems like chronic fatigue syndrome, ADHD, and Alzheimer’s disease. 

The progress in new pharmacology has slowed in a few areas. Yet, the substance still attracts the interest of researchers for being a unique atypical inhibitor of dopamine. As it doesn’t induce cytochrome P450 enzymes, it might be preferred over modafinil in experiments. 

Since experts study its potential in improving cognitive functions, it becomes relevant to cognitive research. This blog explains the flmodafinil tablet’s pharmaceutical properties, its effects, and recent studies on its applications.

What Is Flmodafinil Made Of?

CRL-40 is a synthetic substance that is a racemic mixture. So, it contains two forms that are mirror images (called enantiomers): (S)-(+)-flmodafinil (JBG1-048) and (R)-(–)-flmodafinil (JBG1-049). In the body, these enantiomers act differently. The (S)-form is more likely to act on the dopamine transporter. 

This nootropic compound is an analog of modafinil. Its chemical structure is almost the same, but a few modifications were made for performance improvement. More specifically, it has two fluorine atoms on its phenyl rings, compared to modafinil. This may further stabilize and potentiate the compound. 

Other related compounds are armodafinil ((R)-modafinil), esmodafinil ((S)-modafinil), adrafinil, and fladrafinil. These have similarities but are slightly different in their structure and effects on the brain. Flmodafinil is chemically designed to be more targeted and potentially more effective in promoting wakefulness and easily enhancing mood. 

The background of Flmodafinil

Flmodafinil capsules are a special form of modafinil that keeps users more alert and clear-headed. The patent for the tyrosinase inhibitor was granted in 2013, and research in mice started in December 2015. In 2015, NLS Pharmaceutics, a Swiss bio pharmaceutical company, developed the compound. Its main focus is on treatments for central nervous system problems. 

This nootropic contains two enantiomers, (S)-(+)-flmodafinil (JBG1-048) and (R)-(–)-flmodafinil (JBG1-049). Both show different effects on the body. The compound was initially studied as a possible treatment for chronic fatigue syndrome, idiopathic hypersomnia, narcolepsy, attention deficit hyperactivity disorder (ADHD), and Alzheimer’s disease. 

Its development has been discontinued for narcolepsy, ADHD, and Alzheimer’s disease. However, it is still being studied in labs for chronic fatigue syndrome. While banned for certain clinical research, it attracts attention from scientists due to its potential as a cognitive enhancer. 

Pharmacodynamics of Flmodafinil

Mode of Action

Flmodafinil causes dopamine in the brain to rise by blocking the dopamine transporter (DAT). It is as a selective dopamine reuptake inhibitor (DRI), just like modafinil, but with better specific benefits. Moreover, it blocks 83% of DAT, more than methylphenidate can. It also does not significantly influence the adrenergic system, advancing its use for rosacea.

Easy Binding To Receptors

 It interacts differently with each receptor, with unique levels of strength (Ki values).

• Dopamine transporter (DAT) with 4,090 nM.
• Serotonin transporter (SERT) with 48,700 nM (about 12 times weaker than DAT).
• Binding of sigma-1 (σ1) receptor by ketamine is very weak, as Ki is greater than 100,000 nM.

It signifies that CRL-40,940 primarily targets dopamine and interacts little with the rest of the neurotransmitter systems, which keeps the side effects low.

Enantiomers react differently when performing the same chemical reaction.

 There are two forms of flmodafinil (enantiomers), and each has its own level of potency.

• The selective compound (S)-(+)-Flmodafinil (JBG1-048) has a strength of 2,970 nM 
• The strength of (R)-(–)-Flmodafinil (JBG1-049) is 4,830 nM
• The strength of Armodafinil ((R)-modafinil) is 5,480 nM

It indicates that the affinity of the (S)-form of flmodafinil for dopamine transport receptors is greatest compared to the other compounds.

Increases Levels of Dopamine

Flmodafinil tablets can raise dopamine levels in the nucleus accumbens by up to twice (150-200%) at the highest administered dose. The amount is much lower than that of Amphetamines or cocaine produced. It means that the misuse is less likely with this nootropic compound.

Wakefulness and Impact on Sleep

About flmodafinil for sale, when compared to modafinil:

• Keeps people more awake for a longer period
• Don’t result in trouble sleeping once the medication wears off

Thus, it has a better safety profile for prolonged study during waking hours, but still requires more evidence.

Advantages in Drug Metabolism

Cytochrome P450 enzymes (CYP3A4 and CYP3A5) are not activated by flmodafinil in the same way as modafinil does. As it lowers the risks of drug-drug interactions, it is a good option for use in challenging scientific studies.

Comparison with Modafinil and Other Nootropics

Although Flmodafinil CRL-40 940 is a next-generation nootropic like modafinil, some differences make it even better and safer. For instance, it boosts wakefulness by suppressing the dopamine transporter (DAT). Due to the two fluorine atoms, bisfluoromodafinil might be more likely to stay in the body and be easily absorbed. It possibly has long-lasting effects compared to its counterparts. 

Flmodafinil is better for research and clinical use than modafinil since it does not induce the CYP3A4 cytochrome P450 enzymes. This difference has made this compound a potentially safer and more efficient cognitive drug.

Can people legally use Flmodafinil?

If you are wondering whether you can buy Flmodafinil as a normal person, then the answer is no. It is solely for research purposes and illegal to use for personal consumption. One of the reasons behind it is that it is still in the research phase for chronic fatigue syndrome. Therefore, it is not for medical purposes in the United States, the United Kingdom, or the European Union. 

You can buy Flmodafinil online for ethical research purposes. However, shop it from a trusted platform that offers premium products while maintaining high standards, like Kimera Chems. Users, scientists, and students need to follow the correct procedures while handling this nootropic compound. 

Final Verdict 

The research nootropic compound known as flmodafinil or bisfluoromodafinil has close links to modafinil. Its popularity comes from the ability to sharpen the mind and focus without causing extreme stimulation of the nerves. Initially, it was studied for conditions like chronic fatigue syndrome and ADHD, and it does this by selectively blocking the dopamine transporter. 

Bisfluoromodafinil acts differently from strong stimulants because it is unlikely to give rise to serious side effects, like sleep disturbance. Flmodafinil CRL-40 940 is still being studied in many parts of the world and has not been approved by the FDA. Overall, researchers can explore brain function and look for cognitive benefits with a wiser and safer next-generation nootropic.