Calculated reference model · not an experimental or batch-certified structure. All 20 atoms shown.
Model data & sources
- Heavy atoms only; hydrogens are omitted from the reference display.
- Source-defined stereochemistry is checked against the calculated coordinates; no energy-minimum, crystal or solution-structure claim is made.
- The source record leaves some stereochemistry unspecified. This calculated conformer does not establish a unique stereoisomer.
- Reference molecular species only; batch identity, purity, counterions and excipients are not certified.
- Formula
- C13H15FN2O3S
- Method
- RDKit ETKDGv3 / MMFF94s calculated reference conformer
Unifiram
Unifiram (DM-232) Research Standard
Unifiram (DM-232) is a synthetic research compound classified within the sulfonyl-pyrrolopyrazinone chemical family. In laboratory research, it is utilized as a high-affinity ligand for investigating the pharmacology of the AMPA receptor complex. By providing a chemically defined reference material, Unifiram enables detailed studies into glutamate receptor subtype interactions and the mapping of ligand-receptor association sites. It is frequently employed in computational and in vitro models to explore the structural basis of glutamatergic signaling and receptor modulation.
Physical & Handling Properties
| Property | Specification |
|---|---|
| Physical Appearance | Fine, white to off-white homogeneous powder |
Mechanism of Action & Research Context
Unifiram is examined primarily for its role as a ligand within the central nervous system's glutamatergic pathways.
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Receptor Interaction: Investigations focus on the compound’s activity at AMPA receptor complexes. It serves as a probe to analyze binding kinetics and the structural requirements for receptor modulation.
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Structural Modeling: Given its molecular architecture, the compound is a frequent subject for computational docking studies, which aim to predict ligand-receptor fit and the specific conformational changes that result from binding.
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Glutamate Signaling: Research models utilize Unifiram to perturb and observe signaling patterns in glutamate receptor subtypes, contributing to a better fundamental understanding of synaptic transmission dynamics.
Research Applications
Unifiram is a specialized reagent essential for molecular modeling and neurochemical signaling research.
Primary fields of in vitro and computational laboratory investigation include:
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Receptor Binding Assays: Utilizing the compound in competitive binding studies to determine affinity for specific glutamate receptor subtypes.
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Molecular Docking: Applying computational techniques to examine the structural fit of the sulfonyl-pyrrolopyrazinone scaffold within receptor binding sites.
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Structure-Activity Research (SAR): Comparative analyses against structurally related compounds to determine the key pharmacophores for activity.
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In Vitro Signal Analysis: Observing the effects of the compound in cellular models to measure downstream signaling changes.
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Analytical Method Development: Serving as a standardized reference material for chromatography and mass spectrometry assays.
Storage & Handling Guidelines
Store at controlled room temperature. Keep tightly closed.
Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.
Related Research Compounds
Research Use Disclaimer
Research Use Only Disclaimer: This product is labeled and sold "For Research Use Only — NOT FOR HUMAN CONSUMPTION." It is not a drug, dietary supplement, food, cosmetic, or medical device, and it is not approved by the FDA or any other regulator for human or veterinary use. It is supplied to approved account holders as a research chemical for laboratory use and must be handled in accordance with applicable law.
