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Mazdutide (IBI362 / LY3305677)
Mazdutide (also identified as IBI362 or LY3305677) is a synthetic dual-acting peptide agonist developed to investigate the simultaneous activation of GLP-1 and glucagon receptors. As a key member of the emerging class of multi-receptor ligands, this compound serves as a vital tool for exploring the molecular architecture of dual-receptor interaction and signaling in controlled in vitro environments. By analyzing its alignment within specific receptor pockets, researchers can better map the docking mechanics and cascade activations associated with multi-target peptide therapies.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | Mazdutide (IBI362 / LY3305677) |
| Chemical Formula | C210H322N46O67 |
| Molecular Weight | 4563.1 g/mol |
| Physical Appearance | White to off-white lyophilized powder |
| Assay Purity | Refer to the batch-specific Certificate of Analysis (COA) supplied for the lot received |
Research Applications
Mazdutide is utilized as a specialized tool for mapping the interplay between glucagon and GLP-1 receptor pathways in controlled laboratory models.
Primary fields of in vitro laboratory investigation include:
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Receptor Affinity Mapping: Quantifying binding efficiency across GLP-1 and glucagon receptor targets.
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Dual Agonist Analysis: Investigating the concurrent activation and intracellular signaling pathways triggered by dual-receptor engagement.
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Signal Transduction Studies: Examining the molecular cascades and metabolic outputs activated in cell-based assays.
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Structural Stability Tests: Investigating peptide chain integrity and conformation in varying chemical environments.
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In Vitro Validation: Utilizing laboratory protein-ligand models to map precise docking and interaction sites.
Storage & Handling Guidelines
To maintain the stability and experimental validity of the lyophilized peptide, the following laboratory protocols are required:
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Lyophilized Material: Store at room temperature, ensuring the material is kept away from direct light.
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Reconstituted Material: Samples should be kept in a refrigerator.
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Long-Term Storage: The material must be stored in a freezer.
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Environmental Control: Store with a desiccant in a dry area and ensure the vial remains tightly closed.
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Aseptic Technique: Utilize sterile tools and clean laboratory spaces during reconstitution to prevent contamination.
Related Research Compounds
Research Use Disclaimer
Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medication, or dietary supplement, and is strictly prohibited for human or animal consumption. Kimera Chems supplies these research materials solely to qualified institutions and professional investigators for authorized study.
