KimeraCHEMS- C
- N
- O
Calculated reference model · not an experimental or batch-certified structure. All 22 atoms shown.
Model data & sources
- Heavy atoms only; hydrogens are omitted from the reference display.
- Source-defined stereochemistry is checked against the calculated coordinates; no energy-minimum, crystal or solution-structure claim is made.
- Reference molecular species only; batch identity, purity, counterions and excipients are not certified.
- Formula
- C18H14N2O2
- Method
- RDKit ETKDGv3 / MMFF94s calculated reference conformer
- Batch
- KC-SL3-04
SLU-PP-332
Nuclear Receptor LigandsPublished formats
- Dry-Fill Capsule 60ct/250mcg/15mg
- Liquid Dropper 30ml/500mcg per ml/15mg
- Aliquot Vial 10ml/25mg per ml/250mg
- Liquid Dropper 30ml/40mg per ml/1.2g
- Powder 1g
- Hygroscopic Matrix 50ml/20mg per ml/1g
- Dry-Fill Capsule 60ct/20mg/1.2g
What is the difference between these?
- Dry-Fill Capsule
- Capsules filled with the weighed solid. The label gives the amount in each capsule and the number in the bottle.
- Liquid Dropper
- The compound already in solution, in a dropper bottle. The label gives the amount per millilitre, the bottle volume and the total.
- Aliquot Vial
- The compound already in solution, in a small sealed vial. Less volume than the dropper bottle and more per millilitre, so read the total rather than the size. Where a carrier is used it is named in brackets.
- Powder
- Raw material as a solid. Nothing added and nothing portioned; the stated weight is what is in the container.
Supplementary product details from the published catalog, checked 2026-10-07. These reference details do not establish current availability.
Pricing
Pricing and order placement are reserved for reviewed research accounts. Log in or submit an account application to view current product pricing.
Technical Specifications
Batch COA Database ↗Identity fields from the published product record, checked 2026-10-07. Reference information is not a batch identity certificate.
Research Overview
SLU-PP-332 (ERR Pan-Agonist) Research Standard
SLU-PP-332 is a potent, synthetic small-molecule pan-agonist of the Estrogen-Related Receptors (ERRs), specifically targeting ERR-alpha, ERR-beta, and ERR-gamma. Built on a hydrazone scaffold that links a 4-hydroxybenzohydrazide core to a naphthalene ring system, this compound is a vital tool for studying mitochondrial metabolism and the transcriptional programs associated with oxidative energy expenditure. Often cited in literature as an "exercise mimetic," SLU-PP-332 is employed to isolate and investigate the PGC-1-alpha-linked gene programs that drive mitochondrial biogenesis and fatty-acid oxidation at the nuclear-receptor level.
Additional Properties
| Property | Specification |
|---|---|
| Target(s) | ERR-alpha (primary), ERR-beta, ERR-gamma |
| Physical Appearance | Solid |
| Solution Base | Liquid: PEG400, DMSO; Aliquot Vial: Propylene Glycol, PEG400, Benzyl Benzoate, Benzyl Alcohol |
Mechanism of Action & Research Context
SLU-PP-332 provides a direct mechanism to modulate the ERR-driven transcriptional machinery, distinguishing its mode of action from upstream energy sensors.
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ERR Isoform Agonism: The compound stabilizes the active conformation of all three ERR isoforms, with the highest relative potency at ERR-alpha (EC50 ≈ 98 nM).
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Transcriptional Regulation: By promoting the recruitment of coactivators to the ERR binding sites, SLU-PP-332 triggers the upregulation of genes involved in mitochondrial biogenesis and fatty-acid oxidation.
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Direct Nuclear Receptor Modulation: Unlike adrenergic agonists or AMPK activators, which modulate mitochondrial activity through indirect signaling cascades, SLU-PP-332 acts directly at the nuclear receptor level to program the metabolic phenotype.
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Selectivity: The compound demonstrates high selectivity for ERRs over classical Estrogen Receptors (ER-alpha/ER-beta) and other related nuclear receptors, making it a reliable tool for isolating ERR-specific biological effects.
Research Applications
SLU-PP-332 is a specialized reagent essential for modern metabolic and biochemical research.
Primary fields of in vitro laboratory investigation include:
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Mitochondrial Biogenesis Research: Studying the molecular pathways that increase mitochondrial density and oxidative capacity.
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Metabolic Signaling: Modeling the transcriptional adaptations of endurance exercise by upregulating PGC-1-alpha-linked gene programs.
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Fatty-Acid Oxidation Studies: Investigating the enzymatic and transcriptional shifts in lipid metabolism within isolated cell lines.
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Nuclear Receptor Profiling: Utilizing the compound to map the interactome of ERR isoforms and their downstream targets in oxidative tissue.
Storage & Handling Guidelines
Store at controlled room temperature. Keep tightly closed. Liquid formats: do not refrigerate or freeze. Cold storage may cause the solution to cloud or precipitate. If this occurs, return to room temperature and mix until clear.
Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.
Related Research Compounds
Further reading: SLU-PP-332 research overview
Research Use Disclaimer
Research Use Only Disclaimer: This product is labeled and sold "For Research Use Only - NOT FOR HUMAN CONSUMPTION." It is not a drug, dietary supplement, food, cosmetic, or medical device, and it is not approved by the FDA or any other regulator for human or veterinary use. It is supplied to approved account holders as a research chemical for laboratory use and must be handled in accordance with applicable law.
Certificates of Analysis
- Batch KC-SLU-02 1 report
- Batch KC-SL3-04 2 reports
- Batch KC-SL3-03 1 report
Currently shipping from batch KC-SL3-04.
Compounds That Survive Scrutiny
Research use only. Not for human or veterinary use.