SLU-PP-915

CAS: 2285432-92-8
Molecular wt: 341.16
Compound class: 2,5-disubstituted thiophene amide / phenylboronic acid

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Batch: KC-SL9-01

Reports: 3 on file

This batch is what the Liquid Dropper is made from. The other forms on this page come from different material and carry their own codes on the label. Several lots of this batch are on the shelf. Your bottle’s lot code is printed on its label, and every lot of this batch is covered by the same certificate.

SLU-PP-915

This product is intended for research and laboratory use only. It is not intended for human consumption, veterinary use, or any therapeutic applications. By purchasing this product, the buyer agrees to use it solely for research purposes in accordance with all applicable local, state, and federal regulations.

What is the difference between these?

Dry-Fill Capsule: Capsules filled with the weighed solid. The label gives the amount in each capsule and the number in the bottle.
Liquid Dropper: The compound already in solution, in a dropper bottle. The label gives the amount per millilitre, the bottle volume and the total.
Powder: Raw material as a solid. Nothing added and nothing portioned; the stated weight is what is in the container.

Each label gives the amount per unit and the total, so compare the totals rather than the container size.

Description

SLU-PP-915 (ERR Pan-Agonist) Research Standard

SLU-PP-915 is a synthetic small-molecule pan-agonist of the Estrogen-Related Receptor (ERR) family, specifically targeting ERRα, ERRβ, and ERRγ. Developed as a second-generation analog of SLU-PP-332, this compound incorporates a phenylboronic acid pharmacophore that preserves potent ERR activation while significantly enhancing metabolic stability and oral bioavailability. As an “exercise mimetic,” SLU-PP-915 is utilized in laboratory research to study the PGC-1α-linked transcriptional programs that regulate mitochondrial biogenesis, fatty-acid oxidation, and autophagy-lysosomal function.

Technical Specifications

Property	Specification
Product Name	SLU-PP-915
CAS Number	2285432-92-8
Chemical Formula	C₁₇H₁₃BFNO₃S
Molecular Weight	341.16 g/mol
Chemical Class	2,5-disubstituted thiophene amide / phenylboronic acid
Target(s)	ERRα, ERRβ, ERRγ (Pan-agonist)
Physical Appearance	Brown Crystalline solid
Assay Purity	Refer to the batch-specific Certificate of Analysis (COA) supplied for the lot received
Solution Base	PEG400, DMSO

Mechanism of Action & Research Context

SLU-PP-915 modulates metabolic phenotype by directly activating nuclear receptors that function as master transcriptional regulators of oxidative metabolism.

ERR Isoform Agonism: SLU-PP-915 binds the ligand-binding domain of all three ERR isoforms, with reported EC50 values of approximately 414 nM (ERRα), 435 nM (ERRβ), and 378 nM (ERRγ) in cell-based co-transfection assays.
Transcriptional Regulation: The compound promotes the recruitment of coactivators to drive the expression of canonical ERR target genes such as PGC1α, PDK4, and LDHA. It is notably selective for the ERR subfamily, demonstrating no significant activity at classical estrogen receptors (ERα or ERβ).
Autophagy-Lysosomal Axis: Beyond mitochondrial biogenesis, SLU-PP-915 upregulates Transcription Factor EB (TFEB) and downstream markers (e.g., LAMP1, LAMP2, CTSD), providing a mechanism to study the coordination between metabolic demand and autophagic clearance in cardiac and skeletal muscle models.
Structural Optimization: The substitution of the phenolic hydrogen-bond donor (found in SLU-PP-332) with a phenylboronic acid group was a strategic development to improve microsomal stability, allowing for oral administration in murine models.

Research Applications

SLU-PP-915 serves as a high-precision chemical probe for isolating the effects of chronic ERR activation.

Primary fields of in vitro and in vivo laboratory investigation include:

Exercise Mimetic Research: Evaluating transcriptional signatures and exercise capacity (e.g., time-to-exhaustion) in murine treadmill models.
Mitochondrial Biogenesis & Oxidative Metabolism: Quantifying mitochondrial density and oxidative phosphorylation efficiency in response to pharmacologically induced ERR activation.
Cardiac Function: Investigating the protective effects of ERR activation in pressure-overload heart failure models (e.g., transaortic constriction), particularly regarding lipid metabolism and TFEB-mediated autophagy.
Metabolic Reprogramming: Mapping shifts in substrate utilization (e.g., increased fatty acid oxidation) driven by ERR-mediated gene networks.

Storage & Handling Guidelines

Store at controlled room temperature. Keep tightly closed. Liquid formats: do not refrigerate or freeze. Cold storage may cause the solution to cloud or precipitate. If this occurs, return to room temperature and mix until clear.

Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.

Related Research Compounds

Further reading: SLU-PP-915 research overview

Research Use Disclaimer

Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medical treatment, dietary supplement, or food ingredient, and is strictly prohibited for human or animal consumption. Kimera Chems supplies this research material solely to qualified institutions and professional investigators for authorized laboratory research.

Compound Class	2,5-disubstituted thiophene amide / phenylboronic acid
CAS Number	2285432-92-8
Other Names	DA-57928
IUPAC Name	[3-[5-[(2-fluorophenyl)carbamoyl]thiophen-2-yl]phenyl]boronic acid
Molecular Formula	C₁₇H₁₃BFNO₃S
Molecular Weight	341.16
Capsule Concentration	10mg x 60ct
Liquid Concentration And Solution	20mg/ml PEG400, DMSO
Bulk Powder Quantity	1g

Certificates of Analysis

Batch KC-SL9-01

3 reports

Currently shipping from batch KC-SL9-01.

Powder orders ship from batch KC-SL9-01.

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Research Use Only
All products supplied by Kimera Chems LLC are intended strictly for laboratory research use. They are not drugs, dietary supplements, food, cosmetics, or veterinary products, and are not for human or animal consumption.

Regulatory Status
Kimera Chems LLC is a chemical supplier. Kimera Chems is not a compounding pharmacy or chemical compounding facility as defined under Section 503A of the Federal Food, Drug, and Cosmetic Act, and is not an outsourcing facility as defined under Section 503B of that Act.

Intended Use and Handling
The products we offer are not intended for human use. They are intended for in-vitro and pre-clinical research purposes only. The customer acknowledges that risks exist in the handling, use, and distribution of these products, and certifies that it has the proper equipment, facilities, and personnel to manage those risks, and knowingly accepts them. These chemicals are not intended to be used, and should not be used, in inappropriate applications — including, without limitation, as food additives, drugs, cosmetics, or household chemicals, or in any application outside of in-vitro laboratory research, pre-clinical research, or laboratory chemical synthesis and materials testing.

Customer Responsibility
By purchasing these products, the customer agrees to the above. In the event the customer uses, or causes others to use, these products outside of these restrictions, the customer accepts all risk of doing so, absolves Kimera Chems of any responsibility for such actions, and agrees to indemnify and hold Kimera Chems harmless against any third-party claims arising from them.