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L-Tetrahydropalmatine (L-THP)
L-Tetrahydropalmatine (L-THP) is the levorotatory enantiomer of tetrahydropalmatine, a tetracyclic protoberberine-type isoquinoline alkaloid isolated from plants of the Corydalis and Stephania genera. As an isolated stereoisomer, L-THP is utilized in receptor-based research due to the distinct pharmacological activity of the (−)-enantiomer compared to its racemate or the (+)-enantiomer. It is primarily used as a multi-receptor probe in monoamine receptor research.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | L-Tetrahydropalmatine (L-THP) |
| IUPAC Name | (−)-Tetrahydropalmatine |
| CAS Number | 483-14-7 |
| Molecular Formula | C21H25NO4 |
| Molecular Weight | 355.43 g/mol |
| Chemical Class | Protoberberine isoquinoline alkaloid |
| Appearance | White to off-white crystalline powder |
| Solubility | Poor in water; soluble in DMSO and organic solvents |
| Assay Purity | Refer to the batch-specific Certificate of Analysis (COA) supplied for the lot received |
Pharmacology & Research Context
L-THP is characterized by broad, moderate-affinity engagement across multiple monoamine receptor families, acting as an antagonist at dopamine D1, D2, and D3 receptors, with additional affinity at α-adrenergic and serotonergic sites. Consequently, it functions effectively as a multi-receptor probe in in vitro assays rather than a highly selective tool compound.
Safety Warning: Hepatotoxicity
L-THP is a documented cause of drug-induced liver injury. It has been associated with cases of acute hepatitis and, in historical contexts involving traditional preparations, serious toxicological events. L-THP is not FDA-approved for any indication. Investigators should treat this compound as a known hepatotoxin and utilize appropriate laboratory safety protocols when handling.
Research Applications
L-THP is utilized for its role in investigating dopaminergic signaling and monoamine receptor dynamics.
Primary fields of in vitro laboratory investigation include:
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Receptor Binding Studies: Mapping affinity profiles across dopamine, adrenergic, and serotonergic receptor families.
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Monoamine System Probing: Utilizing the compound as a multi-receptor agent in neurobiological cell models.
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Structural/Enantiomeric Analysis: Comparative research between L-THP, the racemate, and the (+)-enantiomer.
Storage & Handling Guidelines
Store at controlled room temperature. Keep tightly closed.
Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.
Related Research Compounds
Research Use Disclaimer
Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, food, cosmetic, or dietary supplement, and is strictly prohibited for human or animal consumption. Kimera Chems supplies these research materials solely to accredited institutional laboratories and qualified scientific investigators.
