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Calculated reference model · not an experimental or batch-certified structure. All 37 atoms shown.

Model data & sources
  • Heavy atoms only; hydrogens are omitted from the reference display.
  • Source-defined stereochemistry is checked against the calculated coordinates; no energy-minimum, crystal or solution-structure claim is made.
  • Reference molecular species only; batch identity, purity, counterions and excipients are not certified.
Formula
C26H37N5O5S
Method
RDKit ETKDGv3 / MMFF94s calculated reference conformer
In stock nowBrowse more certificates
Batch 1 of 2
KC-MID-02
Batch 2 of 2
KC-MRD-03
The forms on this page come off different batches, so more than one code is shipping. Each has its own certificate, and the code printed on your label is the one you have.

Mirodenafil

Phosphodiesterase Inhibitors

Published formats

  • Dry-Fill Capsule 60ct/50mg/3g
  • Liquid Dropper 30ml/50mg per ml/1.5g
  • Powder 5g
What is the difference between these?
Dry-Fill Capsule
Capsules filled with the weighed solid. The label gives the amount in each capsule and the number in the bottle.
Liquid Dropper
The compound already in solution, in a dropper bottle. The label gives the amount per millilitre, the bottle volume and the total.
Powder
Raw material as a solid. Nothing added and nothing portioned; the stated weight is what is in the container.
Each label gives the amount per unit and the total, so compare the totals rather than the container size.

Supplementary product details from the published catalog, checked 2026-10-07. These reference details do not establish current availability.

Pricing

Pricing and order placement are reserved for reviewed research accounts. Log in or submit an account application to view current product pricing.

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Technical Specifications

Batch COA Database ↗
CAS Registry Number862189-95-5
Molecular FormulaC₂₆H₃₇N₅O₅S
Molecular Weight531.67
IUPAC Designation5-ethyl-2-[5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-7-propyl-3H-pyrrolo[3,2-d]pyrimidin-4-one
Physical FormWhite to off-white powder
Storage RequirementsRefer to product documentation
Solution VehiclePEG400, DMSO, PS80
Other NamesMirodenafil Dihydrochloride
Capsule Concentration50mg x 60ct
Liquid Concentration and Solution50mg/ml PEG400, DMSO, PS80
Bulk Powder Quantity5g

Identity fields from the published product record, checked 2026-10-07. Reference information is not a batch identity certificate.

Research Overview

Mirodenafil (SK-3530) Overview

Mirodenafil (SK-3530) is a synthetic, selective phosphodiesterase-5 (PDE5) inhibitor. It functions by inhibiting the PDE5 enzyme, which is responsible for the degradation of cyclic guanosine monophosphate (cGMP) in smooth muscle tissue. By preventing this degradation, mirodenafil facilitates the accumulation of cGMP, thereby promoting nitric oxide–mediated vasodilation. It is primarily used in laboratory research to investigate NO-cGMP signaling cascades, vascular smooth muscle physiology, and comparative PDE5 pharmacology.

Physical & Handling Properties

Property Specification
Appearance White to off-white powder
Solution Base PEG400, DMSO, PS80

Mechanism of Action & Research Utility

As a selective PDE5 inhibitor, mirodenafil is utilized to study the regulation of vascular smooth muscle tone and endothelial function.

  • Enzymatic Inhibition: Competitively binds to the PDE5 catalytic site, preventing the hydrolysis of cGMP to 5′-GMP.

  • Signaling Modulation: Enhances nitric oxide (NO) signaling pathways, which are critical for vascular relaxation.

  • Pharmacological Profiling: Serves as a reference compound in studies comparing the potency, selectivity, and structure-activity relationships (SAR) of various PDE5 inhibitors.

Research Applications

Mirodenafil is a specialized tool used for examining vascular biology and cyclic nucleotide signaling in laboratory models.

Primary fields of in vitro and ex vivo laboratory investigation include:

  • PDE5 Inhibition Studies: Mapping enzyme kinetics and structural binding profiles.

  • Vascular Biology: Researching the relaxation mechanisms of vascular smooth muscle and endothelial pathways.

  • Comparative Pharmacology: Evaluating the efficacy of different heterocyclic scaffolds in inhibiting PDE5 relative to other inhibitors (e.g., sildenafil, vardenafil).

  • Signaling Pathways: Investigating NO-cGMP cross-talk in isolated tissue or cell-based models.

Storage & Handling Guidelines

Store at controlled room temperature. Keep tightly closed. Liquid formats: do not refrigerate or freeze. Cold storage may cause the solution to cloud or precipitate. If this occurs, return to room temperature and mix until clear.

Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.

Related Research Compounds

Research Use Disclaimer

Research Use Only Disclaimer: This product is labeled and sold "For Research Use Only — NOT FOR HUMAN CONSUMPTION." It is not a drug, dietary supplement, food, cosmetic, or medical device, and it is not approved by the FDA or any other regulator for human or veterinary use. It is supplied to approved account holders as a research chemical for laboratory use and must be handled in accordance with applicable law.

Certificates of Analysis

Currently shipping from batches KC-MID-02 and KC-MRD-03. The code printed on your label says which one you have.

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Research use only. Not for human or veterinary use.