Structure Context: The model depicts the ibutamoren parent molecule. The published product is ibutamoren mesylate; the mesylate counterion is not drawn. The product specifications identify the salt separately.
Calculated preset reference · not batch-certified. 37 non-hydrogen atoms shown; hydrogens omitted.
Model data & sources
- Depicted Formula
- C27H36N4O5S
- Depicted CAS
- 159634-47-6
- Depicted Form
- Ibutamoren parent molecule
- Product Form
- Ibutamoren mesylate
- Calculation method
- RDKit · ETKDGv3 · MMFF94
MK-677 (Ibutamoren)
MK-677 (Ibutamoren) Research Standard
MK-677 (ibutamoren mesylate) is a non-peptide agonist of the growth hormone secretagogue receptor (GHS-R1a) built on a spiro[indoline-3,4′-piperidine] scaffold. It is a reference ligand for GHS-R1a binding, signal transduction and analytical method development.
Physical & Handling Properties
| Property | Specification |
|---|---|
| Salt Form | Mesylate |
| Physical Appearance | White to off-white crystalline powder |
| Solution Base | Propylene Glycol, DMSO |
Mechanism of Action & Research Context
MK-677 functions as a non-peptide ghrelin mimetic, interacting directly with GHS-R1a to modulate the endocrine system.
-
Receptor Selectivity: Agonist at GHS-R1a, used to define binding affinity and selectivity against related GPCRs.
-
Signal Transduction: Gq-coupled calcium mobilization and IP accumulation readouts in GHS-R1a-expressing cell lines.
Research Applications
MK-677 serves as a benchmark tool in laboratory settings for investigating the ghrelin receptor and broader endocrine pharmacology.
Primary fields of in vitro laboratory investigation include:
-
GHS-R1a Signaling: Examining receptor binding, signal transduction, and transactivation pathways.
-
Comparative Secretagogue Pharmacology: Comparing binding and functional potency across secretagogue chemotypes (e.g., capromorelin, anamorelin) at GHS-R1a.
-
Analytical Method Development: Reference material for LC-MS identification, retention-time matching and in vitro metabolite characterization.
Storage & Handling Guidelines
Store at controlled room temperature. Keep tightly closed. Liquid formats: do not refrigerate or freeze. Cold storage may cause the solution to cloud or precipitate. If this occurs, return to room temperature and mix until clear.
Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.
Related Research Compounds
Further reading: MK-677 (Ibutamoren) research overview
Research Use Disclaimer
Research Use Only Disclaimer: This product is labeled and sold "For Research Use Only — NOT FOR HUMAN CONSUMPTION." It is not a drug, dietary supplement, food, cosmetic, or medical device, and it is not approved by the FDA or any other regulator for human or veterinary use. It is supplied to approved account holders as a research chemical for laboratory use and must be handled in accordance with applicable law.
