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Calculated reference model · not an experimental or batch-certified structure. All 26 atoms shown.

Model data & sources
  • Heavy atoms only; hydrogens are omitted from the reference display.
  • Source-defined stereochemistry is checked against the calculated coordinates; no energy-minimum, crystal or solution-structure claim is made.
  • Reference molecular species only; batch identity, purity, counterions and excipients are not certified.
Formula
C19H16N2O5
Method
RDKit ETKDGv3 / MMFF94s calculated reference conformer
In stock nowBrowse more certificates
Batch
KC-RXT-02
Reports
3 on file
Everything shipping from this page today came off this batch. The code is printed on your label, and one certificate covers the whole batch.

Roxadustat FG-4592

Research Compounds

Published formats

  • Dry-Fill Capsule 30ct/75mg/2.25g
  • Powder 5g
What is the difference between these?
Dry-Fill Capsule
Capsules filled with the weighed solid. The label gives the amount in each capsule and the number in the bottle.
Powder
Raw material as a solid. Nothing added and nothing portioned; the stated weight is what is in the container.
Each label gives the amount per unit and the total, so compare the totals rather than the container size.

Supplementary product details from the published catalog, checked 2026-10-07. These reference details do not establish current availability.

Pricing

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Technical Specifications

Batch COA Database ↗
CAS Registry Number808118-40-3
Molecular FormulaC₁₉H₁₆N₂O₅
Molecular Weight352.35
IUPAC Designation2-[(4-Hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid
Physical FormWhite to pale green solid
Storage RequirementsRefer to product documentation
Other NamesEvrenzo, FG-4592, ASP1517, AZD9941
Capsule Concentration75mg x 30ct
Bulk Powder Quantity5g

Identity fields from the published product record, checked 2026-10-07. Reference information is not a batch identity certificate.

Research Overview

Roxadustat (FG-4592) Research Standard

Roxadustat (FG-4592, ASP 1517) is a potent, synthetic small-molecule inhibitor of the hypoxia-inducible factor prolyl hydroxylase (HIF-PH) enzymes. Characterized by an isoquinoline carboxamide scaffold, this compound serves as a critical biochemical tool for investigating oxygen-sensing pathways and cellular responses to hypoxia. In laboratory research, it is utilized as a competitive inhibitor to map enzyme-substrate interactions, assess binding affinity through kinetic assays, and probe the biochemical regulation of HIF-alpha subunit stability in isolated enzyme systems.

Physical & Handling Properties

Property Specification
Physical Appearance White to pale green solid

Mechanism of Action & Research Context

Roxadustat functions as a competitive inhibitor of the HIF-prolyl hydroxylase (PH) enzymes, which are responsible for the degradation of Hypoxia-Inducible Factor (HIF) under normoxic conditions.

  • Substrate Mimicry: The glycine amide group within the Roxadustat molecule acts as a mimetic of natural substrates, allowing the compound to occupy the enzyme's active site.

  • Active Site Binding: By binding to the site where oxygen and 2-oxoglutarate would normally interact, the molecule prevents the hydroxylation of HIF-alpha subunits.

  • Structural Stabilization: The phenoxy acetic acid moiety provides additional stability to the ligand-enzyme complex, allowing for the precise measurement of binding kinetics in cell-free assays.

Research Applications

Roxadustat is a specialized reagent used to investigate the kinetics and regulatory mechanisms of prolyl hydroxylase enzymes.

Primary fields of in vitro laboratory investigation include:

  • Enzyme Binding Assays: Measuring the efficacy of HIF-PH inhibition in isolated protein preparations and cell-free assay systems.

  • Competition Studies: Observing the displacement of natural substrates by Roxadustat to determine competitive binding characteristics.

  • Binding Affinity (Kinetics): Utilizing kinetic methods to establish inhibition constants and understand the stability of the enzyme-inhibitor complex.

  • Stability & Degradation Testing: Monitoring the chemical degradation of the compound under diverse environmental and solvent conditions to refine laboratory protocol standards.

Storage & Handling Guidelines

Store at controlled room temperature. Keep tightly closed.

Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.

Related Research Compounds

Research Use Disclaimer

Research Use Only Disclaimer: This product is labeled and sold "For Research Use Only — NOT FOR HUMAN CONSUMPTION." It is not a drug, dietary supplement, food, cosmetic, or medical device, and it is not approved by the FDA or any other regulator for human or veterinary use. It is supplied to approved account holders as a research chemical for laboratory use and must be handled in accordance with applicable law.

Currently shipping from batch KC-RXT-02.

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Research use only. Not for human or veterinary use.