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Unifiram (DM-232) Research Standard
Unifiram (DM-232) is a synthetic research compound classified within the sulfonyl-pyrrolopyrazinone chemical family. In laboratory research, it is utilized as a high-affinity ligand for investigating the pharmacology of the AMPA receptor complex. By providing a chemically defined reference material, Unifiram enables detailed studies into glutamate receptor subtype interactions and the mapping of ligand-receptor association sites. It is frequently employed in computational and in vitro models to explore the structural basis of glutamatergic signaling and receptor modulation.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | Unifiram (DM-232) |
| Chemical Formula | C13H15FN2O3S |
| Chemical Class | Sulfonyl-pyrrolopyrazinone |
| Physical Appearance | Fine, white to off-white homogeneous powder |
| Assay Purity | Refer to the batch-specific Certificate of Analysis (COA) supplied for the lot received |
Mechanism of Action & Research Context
Unifiram is examined primarily for its role as a ligand within the central nervous system’s glutamatergic pathways.
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Receptor Interaction: Investigations focus on the compound’s activity at AMPA receptor complexes. It serves as a probe to analyze binding kinetics and the structural requirements for receptor modulation.
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Structural Modeling: Given its molecular architecture, the compound is a frequent subject for computational docking studies, which aim to predict ligand-receptor fit and the specific conformational changes that result from binding.
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Glutamate Signaling: Research models utilize Unifiram to perturb and observe signaling patterns in glutamate receptor subtypes, contributing to a better fundamental understanding of synaptic transmission dynamics.
Research Applications
Unifiram is a specialized reagent essential for molecular modeling and neurochemical signaling research.
Primary fields of in vitro and computational laboratory investigation include:
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Receptor Binding Assays: Utilizing the compound in competitive binding studies to determine affinity for specific glutamate receptor subtypes.
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Molecular Docking: Applying computational techniques to examine the structural fit of the sulfonyl-pyrrolopyrazinone scaffold within receptor binding sites.
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Structure-Activity Research (SAR): Comparative analyses against structurally related compounds to determine the key pharmacophores for activity.
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In Vitro Signal Analysis: Observing the effects of the compound in cellular models to measure downstream signaling changes.
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Analytical Method Development: Serving as a standardized reference material for chromatography and mass spectrometry assays.
Storage & Handling Guidelines
Store at controlled room temperature. Keep tightly closed.
Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.
Related Research Compounds
Research Use Disclaimer
Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medical treatment, dietary supplement, or food ingredient, and is strictly prohibited for human or animal consumption. Kimera Chems supplies this research material solely to qualified institutions and professional investigators for authorized laboratory research.
