1,3-DMAA (Methylhexanamine) Research Standard
1,3-DMAA (1,3-dimethylamylamine; methylhexanamine) is a synthetic aliphatic amine utilized in neuropharmacological and adrenergic research. Structurally categorized as a sympathomimetic amine, 1,3-DMAA acts primarily as an indirect adrenergic agonist. In laboratory research, it serves as a specialized ligand for investigating the structure-activity relationship (SAR) of phenethylamine-like scaffolds and the modulation of norepinephrine release within adrenergic signaling pathways.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | 1,3-DMAA (Methylhexanamine) |
| IUPAC Name | 4-methylhexan-2-amine hydrochloride |
| CAS Number | 13803-74-2 |
| Chemical Formula | C₇H₁₈ClN |
| Molecular Weight | 151.68 g/mol |
| Chemical Class | Aliphatic amine |
| Physical Appearance | Crystalline solid |
| Solubility | Soluble in water and organic solvents |
| Solution Base | Deionized Water, Ethanol, PS80 |
Mechanism of Action & Research Context
The research interest in 1,3-DMAA is defined by its role as an indirect sympathomimetic agent.
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Adrenergic Modulation: 1,3-DMAA acts by stimulating the release of norepinephrine from presynaptic nerve terminals. This mechanism mimics the activity of endogenous catecholamines, making it a useful probe for studying the adrenergic system.
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Sympathomimetic Pharmacology: As a structural analog within the broader class of sympathomimetic amines, it is used to evaluate how small structural changes (such as the aliphatic chain arrangement in 1,3-DMAA) alter potency and efficacy compared to classical phenethylamines.
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Receptor Interaction: Investigations focus on its ability to traverse synaptic membranes and influence catecholamine transporter systems, effectively increasing the concentration of norepinephrine available for post-synaptic adrenergic receptor binding.
Research Applications
1,3-DMAA is a specialized reagent essential for comparative pharmacology and adrenergic signaling research.
Primary fields of in vitro and laboratory investigation include:
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Adrenergic Signaling Pathways: Evaluating the release kinetics and signaling outcomes of norepinephrine modulation in isolated neuronal preparations.
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Structure-Activity Relationship (SAR) Panels: Utilizing 1,3-DMAA as a reference aliphatic amine to determine the influence of specific molecular structures on sympathomimetic activity.
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Receptor Pharmacology: Benchmarking the compound’s activity against other adrenergic ligands to map receptor selectivity and potency within the adrenergic receptor system.
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Molecular Docking & Transporter Analysis: Studying the interaction of the methylhexanamine scaffold with catecholamine transporters to elucidate mechanism-of-action nuances.
Storage & Handling Guidelines
Store at controlled room temperature. Keep tightly closed. Liquid formats: do not refrigerate or freeze. Cold storage may cause the solution to cloud or precipitate. If this occurs, return to room temperature and mix until clear.
Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.
Related Research Compounds
Research Use Disclaimer
Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medical treatment, dietary supplement, or food ingredient, and is strictly prohibited for human or animal consumption. Kimera Chems supplies this research material solely to qualified institutions and professional investigators for authorized laboratory research.
