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Enclomiphene
Enclomiphene is a non-steroidal, synthetic triphenylethylene derivative classified as a selective estrogen receptor modulator (SERM). Structurally, it represents the isolated trans-isomer (E-configuration) of clomiphene citrate, separating it completely from its geometric twin, zuclomiphene (the cis-isomer).
While traditional clomiphene mixtures present a blend of both isomers, investigators study enclomiphene in isolation so that estrogen receptor binding can be measured for one geometric isomer, without the (Z)-isomer present as a second ligand.
Structural Elements to Observe: The molecular architecture of enclomiphene features a signature triphenylethylene backbone substituted with a core chlorine atom and a flexible tertiary amine side chain. It is the rigid stereo-specific E-configuration across the central double bond that governs its specific structural fit within estrogen receptors. This spatial layout governs its binding mode at the estrogen receptor and distinguishes it from the (Z)-isomer in binding assays.
Physical & Handling Properties
| Property | Specification |
|---|---|
| Physical Appearance | Off-white to pale crystalline solid |
| Solubility Profile | Soluble in organic solvents such as anhydrous ethanol and DMSO |
| Solution Base | PEG400, DMSO |
Mechanism of Action & Research Applications
The primary scientific value of enclomiphene is its binding at the estrogen receptor as a single (E)-isomer.
Primary fields of preclinical and in vitro laboratory investigation include:
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Estrogen Receptor Binding: Competitive binding at ERα and ERβ, with Ki values compared against the (Z)-isomer.
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Isomer-Resolved Reference Standard: HPLC method development that separates (E)- and (Z)-clomiphene, with the (Z)-isomer quantified as a specified impurity.
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Comparative SERM SAR: Benchmarking the triphenylethylene scaffold against other SERM chemotypes in receptor binding and reporter assays.
Storage & Handling Guidelines
Store at controlled room temperature. Keep tightly closed. Liquid formats: do not refrigerate or freeze. Cold storage may cause the solution to cloud or precipitate. If this occurs, return to room temperature and mix until clear.
Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.
Related Research Compounds
Further reading: Enclomiphene research overview
Analytical Documentation
Purity, identity, and composition vary by manufacturing lot. Kimera Chems does not publish a single fixed purity figure for this item; refer to the batch-specific Certificate of Analysis (COA) issued for the lot received, which reflects third-party analytical testing for that lot. Contact us if a COA for your lot is required.
Research Use Only Disclaimer: This product is labeled and sold “For Research Use Only — NOT FOR HUMAN CONSUMPTION.” It is not a drug, dietary supplement, food, cosmetic, or medical device, and it is not approved by the FDA or any other regulator for human or veterinary use. It is supplied to approved account holders as a research chemical for laboratory use and must be handled in accordance with applicable law.
