Fasoracetam
Fasoracetam (investigational code NS-105 or LAM-105) is a synthetic, chiral research compound belonging to the racetam family of pyrrolidone derivatives. While sharing the classic core pyrrolidone ring system common to other racetams, Fasoracetam is structurally unique due to its piperidine-1-carbonyl modification at the 5-position. In advanced laboratory models, this distinct geometric configuration shifts its biological target footprint away from simple AMPA receptor modulation, allowing it to interact simultaneously with cholinergic, glutamatergic, and GABAergic pathways. This multi-target versatility makes Fasoracetam an important reference ligand for exploring synaptic plasticity, metabotropic receptor behaviors, and neurochemical signaling cascades.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | Fasoracetam |
| CAS Number | 110958-19-5 |
| IUPAC Name | (5R)-5-(piperidine-1-carbonyl)pyrrolidin-2-one |
| Synonyms | NS-105, LAM-105 |
| Molecular Formula | C₁₀H₁₆N₂O₂ |
| Molecular Weight | 196.25 g/mol |
| Chemical Class | Racetam / Pyrrolidinone Derivative |
| Assay Purity | Refer to the batch-specific Certificate of Analysis (COA) supplied for the lot received |
| Physical Format | White to off-white crystalline powder |
| Solubility Profile | Soluble in water, physiological saline, and polar organic solvents |
Research Applications & Mechanisms of Interest
Fasoracetam is heavily studied in molecular neurobiology and psychopharmacology for its ability to cross-regulate several major neurotransmitter systems simultaneously.
Primary fields of preclinical and in vitro laboratory investigation include:
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Metabotropic Glutamate Receptor (mGluR) Regulation: Investigating how the compound acts as a modulator of metabotropic glutamate receptors (specifically mGluR1, mGluR2/3, and mGluR4/8). Researchers study this activity to model the restoration of glutamatergic balance under states of neurotransmitter hyperexcitotoxicity.
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GABA-B Receptor Up-regulation: Tracking the compound’s unique capacity to increase the density and functional sensitivity of inhibitory GABA-B receptors in cortical and hippocampal membranes after prolonged incubation.
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Cholinergic Release Modulation: Evaluating downstream shifts in cortical acetylcholine (ACh) synthesis and release. Fasoracetam is explored in cholinergic deficit models to track its influence on high-affinity choline uptake (HACU) kinetics.
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Racetam Structure-Activity Relationships (SAR): Serving as a key structural comparator alongside traditional racetams (such as piracetam, aniracetam, and pramiracetam) to analyze how substituting the 5-position of the pyrrolidone ring with a bulky piperidine amide alters receptor binding profiles and lipophilicity.
Storage & Handling Guidelines
To maintain complete stereochemical integrity and ensure highly reproducible analytical baselines:
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Thermal Management: Store the solid reference powder in a cool, dry, and climate-controlled environment. While stable at standard room temperature (15–25°C), long-term master collections are best preserved at -20°C.
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Atmospheric Safeguards: Fasoracetam exhibits low to moderate hygroscopicity. Keep containers hermetically sealed to completely insulate the crystalline lattice from ambient humidity and prevent physical clumping.
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Photolytic Protections: Keep the compound shielded from direct light and intensive UV rays by utilizing original opaque containers or amber glass vials.
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Analytical Quality Standards:Purity for each lot is documented on its batch-specific Certificate of Analysis (COA).
Related Research Compounds
Research Use Only Disclaimer: This product is developed, synthesized, and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug formulation, active pharmaceutical ingredient, licensed medication, or dietary supplement, and is strictly prohibited for direct human or veterinary consumption. Kimera Chems supplies these high-grade chemical batches solely to accredited academic institutions, professional research laboratories, and certified investigators.
