Flmodafinil (CRL-40,940)
Flmodafinil, documented in neuropharmacology literature as CRL-40,940 (and colloquially termed Lauflumide), is a synthetic, bis-fluorinated analog of modafinil. It is characterized by the integration of twin para-fluorine atom substitutions positioned on its core benzhydryl ring matrix, linked directly to a terminal sulfinylacetamide chain. Within translational neuroscience and behavioral modeling, flmodafinil serves as a chemical tool for investigating monoamine transporter binding and reuptake inhibition. The strategic halocarbon modifications alter the compound’s electron density distribution, which researchers study in comparative stability and physicochemical assays against unhalogenated parent molecules.
Structural Attributes to Note: The analytical diagram above highlights the specific bis(4-fluorophenyl)methylsulfinyl architecture that defines Flmodafinil. The central sulfoxide center (-S=O) acts as a chiral axis, flanked by a primary acetamide segment and a di-fluorinated benzhydryl backbone. The robust carbon-fluorine bonds are heavily evaluated in biochemical stability assays to observe how electronic shifts affect resistance against traditional hepatic amide-cleavage and oxidative degradation pathways.
Physical & Handling Properties
| Property | Specification |
|---|---|
| Physical Appearance | White to off-white crystalline solid powder |
| Solution Base | PEG400, DMSO |
Research Applications & Mechanism of Interest
Flmodafinil is used in cell-free and cell-based systems as a reference ligand for the dopamine transporter and for structure-activity comparison within the modafinil series.
Primary fields of in vitro and preclinical laboratory investigation include:
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Dopamine Transporter (DAT) Affinity Kinetics: Measuring competitive binding assays at the dopamine transporter site. Investigators use flmodafinil to measure binding affinity (Ki) and uptake inhibition at DAT.
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Transporter Selectivity Panels: Comparing binding at DAT against the norepinephrine and serotonin transporters (NET, SERT) to define selectivity ratios.
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Comparative Isomeric Structure-Activity Relationships (SAR): Serving as a vital comparative standard alongside modafinil, armodafinil, and adrafinil to map how localized halogen substitution patterns steer receptor selectivity profiles.
Storage & Handling Guidelines
Store at controlled room temperature. Keep tightly closed. Liquid formats: do not refrigerate or freeze. Cold storage may cause the solution to cloud or precipitate. If this occurs, return to room temperature and mix until clear.
Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.
Related Research Compounds
Further reading: Flmodafinil (CRL-40,940) research overview
Research Use Only Disclaimer: This product is labeled and sold “For Research Use Only — NOT FOR HUMAN CONSUMPTION.” It is not a drug, dietary supplement, food, cosmetic, or medical device, and it is not approved by the FDA or any other regulator for human or veterinary use. It is supplied to approved account holders as a research chemical for laboratory use and must be handled in accordance with applicable law.
