Skip to main content
KimeraCHEMS
Display
  • C
  • N
  • O
  • S
  • F

Calculated reference model · not an experimental or batch-certified structure. All 26 atoms shown.

Model data & sources
  • Heavy atoms only; hydrogens are omitted from the reference display.
  • Source-defined stereochemistry is checked against the calculated coordinates; no energy-minimum, crystal or solution-structure claim is made.
  • Reference molecular species only; batch identity, purity, counterions and excipients are not certified.
Formula
C16H17F3N4O2S
Method
RDKit ETKDGv3 / MMFF94s calculated reference conformer
In stock nowBrowse more certificates
Batch
KC-HB1-01
Made
2025-11-18
Reports
2 on file
Everything shipping from this page today came off this batch. The code is printed on your label, and one certificate covers the whole batch.

HBT1 (YDL233C)

Nootropics

Published formats

  • Liquid Dropper 30ml/20mg Per ml/600mg
  • Powder 1g
What is the difference between these?
Liquid Dropper
The compound already in solution, in a dropper bottle. The label gives the amount per millilitre, the bottle volume and the total.
Powder
Raw material as a solid. Nothing added and nothing portioned; the stated weight is what is in the container.
Each label gives the amount per unit and the total, so compare the totals rather than the container size.

Supplementary product details from the published catalog, checked 2026-10-07. These reference details do not establish current availability.

Pricing

Pricing and order placement are reserved for reviewed research accounts. Log in or submit an account application to view current product pricing.

Log in to view priceApply for account

Technical Specifications

Batch COA Database ↗
CAS Registry Number489408-02-8
Molecular FormulaC₁₆H₁₇F₃N₄O₂S
Molecular Weight386.39
IUPAC Designation2-[[2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
Physical FormWhite to off-white solid
Storage RequirementsRefer to product documentation
Solution VehiclePEG400, DMSO
Other NamesAKOS024270212, BS-47734, 2-[[2-[5-Methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
Liquid Concentration and Solution20mg/ml, PEG400, DMSO
Bulk Powder Quantity1g

Identity fields from the published product record, checked 2026-10-07. Reference information is not a batch identity certificate.

Research Overview

HBT1 (YDL233C)

HBT1, also recognized by its screening identifier YDL233C, is a synthetic small-molecule AMPA receptor positive allosteric modulator. The designation YDL233C stems from internal compound indexing during early developmental screenings and does not indicate a yeast origin or any biological derivation. In neuroscience and neuropharmacology research, HBT1 is widely used as a tool compound to investigate the mechanics of excitatory synaptic transmission, cognitive signaling pathways, and long-term potentiation (LTP) models.

Physical & Handling Properties

Property Specification
Physical Appearance White to off-white solid
Solubility Soluble in DMSO and common organic solvents; limited aqueous solubility
Solution Base PEG400, DMSO

Mechanism of Action & Research Utility

HBT1 functions specifically as a positive allosteric modulator of AMPA-type glutamate receptors (AMPAR). Rather than operating as a direct agonist, it amplifies endogenous, glutamate-mediated AMPAR signaling. This distinct heterocyclic scaffold allows investigators to explore targeted receptor-ligand interactions and central nervous system penetration dynamics in experimental models.

In controlled laboratory settings, this allosteric interaction results in:

  • Increased AMPA receptor-mediated synaptic currents.

  • Prolonged receptor open time dynamics.

  • Enhanced excitatory neurotransmission without direct receptor overstimulation.

Research Focus Areas

As a reference standard for synaptic plasticity, HBT1 is primarily examined across several in vitro and laboratory research applications:

  • AMPA Receptor Modulation: Mapping the precise binding pockets and structural kinetics associated with allosteric AMPAkine modulation.

  • Excitatory Synaptic Transmission: Measuring baseline adjustments in synaptic strength and neurotransmitter responses.

  • Synaptic Plasticity & LTP Models: Using the compound to establish cellular baselines for long-term potentiation and synaptic remodeling studies.

  • Neuropharmacology Research: Investigating small-molecule pathways linked to cognitive signaling and neurochemical communication.

Storage & Handling Guidelines

Store at controlled room temperature. Keep tightly closed. Liquid formats: do not refrigerate or freeze. Cold storage may cause the solution to cloud or precipitate. If this occurs, return to room temperature and mix until clear.

Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.

Related Research Compounds

Analytical Documentation

Purity, identity, and composition vary by manufacturing lot. Kimera Chems does not publish a single fixed purity figure for this item; refer to the batch-specific Certificate of Analysis (COA) issued for the lot received, which reflects third-party analytical testing for that lot. Contact us if a COA for your lot is required.

Research Use Only Disclaimer: HBT1 (YDL233C) is intended strictly for research use only. It is a specialized chemical supplied exclusively for non-clinical laboratory analysis and scientific investigation, and is not for human consumption, therapeutic use, or diagnostic application. All handling, compounding, and experimental protocols must comply strictly with regional laws, laboratory safety standards, and qualified investigator regulations.

Certificates of Analysis

Currently shipping from batch KC-HB1-01.

Related products

Kimera Chems

Compounds That Survive Scrutiny

Research use only. Not for human or veterinary use.