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Humanin HNG is the S14G analogue of humanin, a mitochondrial-derived peptide, supplied as a lyophilized powder for laboratory research. A single substitution replaces the serine at position 14 with glycine, giving the sequence Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala (24 residues). Kimera Chems supplies this material for controlled laboratory studies only.
Chemical Composition & Purity
Humanin HNG has the molecular formula C₁₁₈H₂₀₂N₃₄O₃₁S₂ and a molecular weight of 2657.21 g/mol. That is 30.03 g/mol lighter than humanin itself, the difference being the side chain removed at position 14. It appears as a white to off-white lyophilized powder. Purity will be documented on the batch-specific Certificate of Analysis once the first lot is released.
Research Applications
Position 14 has been reported as essential to the activity of the parent peptide, and the glycine substitution at that site is the most widely studied single-residue variant of humanin. Researchers use it as a comparator against the native sequence in binding and structural work.
- Comparative Binding: Measuring affinity alongside native humanin in cell-free systems.
- Structure-Activity Studies: Relating the position-14 substitution to conformation in solution.
- Competitive Assays: Examining displacement of labeled ligands.
- Stability Testing: Monitoring degradation under various conditions.
Storage & Handling Protocol
Store at controlled room temperature, sealed and protected from light.
Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.
Compliance & Usage Disclaimer
This product is for Research Use Only (RUO). It is not for human or animal consumption or clinical application. Kimera Chems supplies Humanin HNG strictly to qualified institutions and researchers.
