Lemairamin

CAS: 29946-61-0
Molecular wt: 311.37
Compound class: Lignan amide (WS-9885B)

Third-party tested. Every batch.

Independent labs test each lot before it ships. The certificates are published here, filed by batch number, for anyone to read.

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Lemairamin

Lemairamin is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms and Conditions prior to ordering.

Description

Lemairamin (WGX-50 / α7nAChR Agonist)

Lemairamin, also identified in research literature as WGX-50, is a synthetic amide derivative characterized by a dimethoxyphenyl group linked to a phenylpropenamide structure. It is extensively utilized in laboratory research as a selective agonist of the α7 nicotinic acetylcholine receptor (α7nAChR). By acting on this specific receptor, Lemairamin serves as a critical probe for investigating pathways related to neuroinflammation, pain hypersensitivity, and neuroprotective signaling mechanisms in cellular models.

Technical Specifications

Property	Specification
Product Name	Lemairamin (WGX-50)
Chemical Formula	C19H21NO3
Molecular Weight	311.37 g/mol
Mechanism	α7 Nicotinic Acetylcholine Receptor Agonist
Appearance	White to off-white powder
Assay Purity	Refer to the batch-specific Certificate of Analysis (COA) supplied for the lot received

Research Applications

Lemairamin is a primary tool for probing the functional role of the α7 nicotinic acetylcholine receptor in various experimental biological contexts.

Primary fields of in vitro laboratory investigation include:

α7nAChR Signaling: Utilizing the compound to trigger and study receptor activation pathways in neuronal and inflammatory cell lines.
Neuroinflammation Research: Analyzing the role of α7nAChR modulation in attenuating inflammatory responses in microglial and astrocytic models.
Pain Hypersensitivity Studies: Probing receptor-mediated pathways involved in the modulation of pain signaling.
Neuroprotective Research: Investigating the compound’s effect on cellular survival pathways under conditions of stress relevant to neurodegenerative research.
Competitive Binding Studies: Evaluating interaction profiles and receptor occupancy in the presence of other nicotinic ligands.

Storage & Handling Guidelines

Store at controlled room temperature. Keep tightly closed.

Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.

Related Research Compounds

Research Use Disclaimer

Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medication, or dietary supplement, and is strictly prohibited for human or animal consumption. Kimera Chems supplies these chemical batches solely to qualified institutions and professional investigators for authorized research purposes.

Compound Class	Lignan amide (WS-9885B)
CAS Number	29946-61-0
Other Names	WGX-50, N-(3,4-Dimethoxy-phenaethyl)-trans-cinnamamid, N-(3,4-dimethoxy-phenethyl)-trans-cinnamamide, (E)-N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-3-phenyl-acrylamide
IUPAC Name	N-(3,4-dimethoxyphenethyl)cinnamamide
Molecular Formula	C₁₉H₂₁NO₃
Molecular Weight	311.37
Capsule Concentration	25mg x 60ct
Bulk Powder Quantity	10g

Certificates of Analysis

Batch KC-LMR-01

2 reports

Powder orders ship from batch KC-LMR-01.

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Research Use Only
All products supplied by Kimera Chems LLC are intended strictly for laboratory research use. They are not drugs, dietary supplements, food, cosmetics, or veterinary products, and are not for human or animal consumption.

Regulatory Status
Kimera Chems LLC is a chemical supplier. Kimera Chems is not a compounding pharmacy or chemical compounding facility as defined under Section 503A of the Federal Food, Drug, and Cosmetic Act, and is not an outsourcing facility as defined under Section 503B of that Act.

Intended Use and Handling
The products we offer are not intended for human use. They are intended for in-vitro and pre-clinical research purposes only. The customer acknowledges that risks exist in the handling, use, and distribution of these products, and certifies that it has the proper equipment, facilities, and personnel to manage those risks, and knowingly accepts them. These chemicals are not intended to be used, and should not be used, in inappropriate applications — including, without limitation, as food additives, drugs, cosmetics, or household chemicals, or in any application outside of in-vitro laboratory research, pre-clinical research, or laboratory chemical synthesis and materials testing.

Customer Responsibility
By purchasing these products, the customer agrees to the above. In the event the customer uses, or causes others to use, these products outside of these restrictions, the customer accepts all risk of doing so, absolves Kimera Chems of any responsibility for such actions, and agrees to indemnify and hold Kimera Chems harmless against any third-party claims arising from them.