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Calculated reference model · not an experimental or batch-certified structure. All 22 atoms shown.

Model data & sources
  • Heavy atoms only; hydrogens are omitted from the reference display.
  • Source-defined stereochemistry is checked against the calculated coordinates; no energy-minimum, crystal or solution-structure claim is made.
  • The source record leaves some stereochemistry unspecified. This calculated conformer does not establish a unique stereoisomer.
  • Reference molecular species only; batch identity, purity, counterions and excipients are not certified.
Formula
C16H15F2NO2S
Method
RDKit ETKDGv3 / MMFF94s calculated reference conformer
In stock nowBrowse more certificates
Batch 1 of 2
KC-MFZ-01
Batch 2 of 2
KC-MFZ-02
The forms on this page come off different batches, so more than one code is shipping. Each has its own certificate, and the code printed on your label is the one you have.

Modafiendz

Nootropics

Published formats

  • Powder 5g
  • Dry-Fill Capsule 60ct/50mg/3g
  • Liquid Dropper 30ml/100mg Per ml/3g
What is the difference between these?
Powder
Raw material as a solid. Nothing added and nothing portioned; the stated weight is what is in the container.
Dry-Fill Capsule
Capsules filled with the weighed solid. The label gives the amount in each capsule and the number in the bottle.
Liquid Dropper
The compound already in solution, in a dropper bottle. The label gives the amount per millilitre, the bottle volume and the total.
Each label gives the amount per unit and the total, so compare the totals rather than the container size.

Supplementary product details from the published catalog, checked 2026-10-07. These reference details do not establish current availability.

Pricing

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Technical Specifications

Batch COA Database ↗
CAS Registry Number1613222-54-0
Molecular FormulaC₁₆H₁₅F₂NO₂S
Molecular Weight323.4
IUPAC Designation2-[[bis(4-fluorophenyl)methyl]sulfinyl]-N-methyl-acetamide
Physical FormWhite to off-white crystalline powder
Storage RequirementsRefer to product documentation
Solution VehiclePEG400, DMSO
Other NamesDehydroxyfluorafinil, N-methyl Dehydroxyfluorafinil, Modafiendz
Capsule Concentration50mg x 60ct
Liquid Concentration and Solution100mg/ml, PEG400, DMSO
Bulk Powder Quantity5g

Identity fields from the published product record, checked 2026-10-07. Reference information is not a batch identity certificate.

Research Overview

Modafiendz (N-methyl-4,4-difluoro Modafinil) Research Standard

Modafiendz (N-methyl-4,4-difluoro Modafinil) is a synthetic, diphenylmethyl-sulfinyl acetamide derivative used in neuroscience research. As a fluorinated analog of the parent compound modafinil, it is studied for its potent interactions with monoamine transporters. It serves as a specialized tool for investigators examining wakefulness-promoting mechanisms, neurotransmitter dynamics, and the structural determinants of Dopamine Transporter (DAT) inhibition in in vitro models.

Physical & Handling Properties

Property Specification
Physical Appearance White to off-white crystalline powder
Solution Base PEG400, DMSO

Mechanism of Action & Research Context

Modafiendz is primarily researched for its role as a ligand at the Dopamine Transporter (DAT).

  • DAT Inhibition: The primary mechanism investigated in laboratory models is the inhibition of the dopamine transporter (DAT). By binding to the transporter, the compound limits the reuptake of dopamine into the presynaptic neuron, thereby increasing extracellular dopamine concentrations in the synapse.

  • Signaling Modulation: Comparative studies utilize Modafiendz to assess how fluorination at the 4,4' positions and N-methylation affects binding affinity and selectivity for DAT compared to modafinil.

  • Neurotransmitter Dynamics: Its investigation often focuses on the resulting modulation of orexin and dopamine signaling cascades, which are key to understanding fatigue-related signaling pathways and alertness.

Research Applications

Modafiendz acts as a focused reference compound for neuropharmacological mapping.

Primary fields of in vitro laboratory investigation include:

  • Transporter Binding Assays: Utilizing radioligand binding or fluorescence-based assays to quantify DAT inhibition constants.

  • Comparative SAR Analysis: Evaluating how structural modifications (fluorination/N-methylation) influence the pharmacological potency of diphenylmethyl-sulfinyl acetamides.

  • Neurotransmitter Pathway Mapping: Investigating the downstream effects of DAT inhibition on orexinergic signaling and catecholamine pathways.

  • Fatigue Models: Employing the compound to measure cellular responses to simulated extended stimulation in controlled laboratory environments.

Storage & Handling Guidelines

Store at controlled room temperature. Keep tightly closed. Liquid formats: do not refrigerate or freeze. Cold storage may cause the solution to cloud or precipitate. If this occurs, return to room temperature and mix until clear.

Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.

Related Research Compounds

Research Use Disclaimer

Research Use Only Disclaimer: This product is labeled and sold "For Research Use Only — NOT FOR HUMAN CONSUMPTION." It is not a drug, dietary supplement, food, cosmetic, or medical device, and it is not approved by the FDA or any other regulator for human or veterinary use. It is supplied to approved account holders as a research chemical for laboratory use and must be handled in accordance with applicable law.

Certificates of Analysis

Currently shipping from batches KC-MFZ-01 and KC-MFZ-02. The code printed on your label says which one you have.

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Research use only. Not for human or veterinary use.