Nooglutyl

Nooglutyl (ONK-10) Research Standard

Nooglutyl (ONK-10) is a synthetic small-molecule conjugate formed by the coupling of 5-hydroxynicotinic acid with L-glutamic acid via an amide bond. As a specialized chemical research tool, Nooglutyl serves as an analytical reference standard for structural studies involving glutamate conjugates. It is important to note that Nooglutyl is chemically distinct from Noopept (omberacetam), and although often conflated in supply-chain materials, they share no structural or pharmacological relationship. This compound is intended for use in high-precision laboratory settings, particularly for method development and structural-activity relationship (SAR) investigations within the glutamatergic research framework.

Physical & Handling Properties

Structural Context & Identity

Nooglutyl represents a unique structural scaffold, specifically an L-glutamic acid residue conjugated to 5-hydroxynicotinic acid.

• Stereochemistry: The compound exists as a single stereocenter in the L-configuration.

• Structural Differentiation: It is frequently misidentified as an analog of Noopept (a dipeptide ethyl ester of the racetam family). Structurally, Nooglutyl is entirely unrelated to the racetam class. This distinction is vital for researchers designing experiments based on specific molecular scaffolds, as the chemical properties and potential interactions of an amide-linked glutamate conjugate differ significantly from those of an ethyl ester dipeptide.

• Analytical Verification: Given its structural complexity, identity is established via HPLC-UV with MS confirmation against a CAS 112193-35-8 reference standard.

Mechanism of Action & Research Context

Verified data regarding the biological mechanism of action for Nooglutyl remains limited, as primary literature originating from the Zakusov Institute of Pharmacology is historically sparse and not broadly accessible for independent verification.

• Current Status: Claims regarding acetylcholine release or specific glutamatergic modulation are common in non-technical literature but lack traceable, peer-reviewed validation.

• Research Approach: Consequently, Nooglutyl is supplied as a reference material. Its primary utility in modern laboratory environments is to provide a clean, scaffold for structural biology and analytical method development, rather than as a tool for testing pre-established or anecdotal pharmacological claims.

Research Applications

Nooglutyl is a specialized reagent for foundational chemical analysis and molecular investigation.

Primary fields of in vitro laboratory investigation include:

• Analytical Method Development: Serving as a standardized analyte for the development of chromatographic separation and mass spectrometry identification techniques.

• Structure–Activity Relationship (SAR) Studies: Utilizing the glutamate conjugate scaffold to probe interactions in glutamatergic research panels.

• Comparative Reference: Acting as a control when evaluating the behavior of amino acid conjugates in isolated systems.

Storage & Handling Guidelines

Store at controlled room temperature. Keep tightly closed.

Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.

References

• Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences. (Primary origin, note: Literature availability limited; independent verification pending).

Related Research Compounds

• HBT1 (YDL233C)
• Sunifiram
• Unifiram

Research Use Disclaimer

Research Use Only Disclaimer: This product is labeled and sold "For Research Use Only — NOT FOR HUMAN CONSUMPTION." It is not a drug, dietary supplement, food, cosmetic, or medical device, and it is not approved by the FDA or any other regulator for human or veterinary use. It is supplied to approved account holders as a research chemical for laboratory use and must be handled in accordance with applicable law.