NSI-189 Phosphate (Neural Growth Research Standard)
NSI-189 Phosphate is a synthetic benzylpiperazine-aminopyridine derivative developed to investigate neurogenic processes and structural synaptic changes within the central nervous system. The compound is supplied as the phosphate salt; salt forms of basic amines are generally more water-soluble than the corresponding free base. It is widely employed as a specialized research tool to map the mechanisms of hippocampal neurogenesis, synaptic density modulation, and the stimulation of neural connectivity in controlled cell-based models.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | NSI-189 Phosphate |
| Chemical Formula | C₂₂H₃₃N₄O₅P |
| Molecular Weight | ~464.49 g/mol |
| Chemical Class | Benzylpiperazine-aminopyridine derivative |
| Physical Appearance | Fine white to off-white/beige powder |
| Assay Purity | Refer to the batch-specific Certificate of Analysis (COA) supplied for the lot received |
Mechanism of Action & Research Context
NSI-189 Phosphate is studied primarily for its potential to stimulate neural cell proliferation and differentiation, particularly within hippocampal tissue models.
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Neurogenic Signaling: Research focuses on its ability to promote the formation of new neurons, tracking neurogenesis via specific biomarkers.
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Synaptic Density Modulation: Investigators utilize the compound to measure changes in synaptic markers, providing insights into the preservation and enhancement of neural connectivity.
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Hippocampal Activation: By applying NSI-189 in in vitro hippocampal tissue models, researchers can examine the up-regulation of signaling pathways associated with long-term potentiation and structural neuroplasticity.
Research Applications
NSI-189 Phosphate is a focused reference standard for studies exploring neurogenesis and neural repair mechanisms.
Primary fields of in vitro laboratory investigation include:
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Neurogenesis Mapping: Tracking new cell formation and differentiation trajectories in hippocampal tissue cultures.
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Synaptic Density Assessment: Measuring shifts in pre- and post-synaptic protein expression in neural models.
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Cellular Marker Analysis: Examining the biochemical signaling cascades induced by NSI-189 in cell-based assays.
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Neural Connectivity Research: Observing the morphological changes and axonal growth patterns of neurons in controlled laboratory environments.
Storage & Handling Guidelines
Store at controlled room temperature. Keep tightly closed.
Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.
References
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Fava M, et al. (2016) A Phase 1B, Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Escalation Study of NSI-189 Phosphate in Patients With Major Depressive Disorder. Molecular Psychiatry. 21(10): 1372–1380.
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Bansal M, et al. (2016) NSI-189, a novel neurogenic compound, prevents cognitive deficit in a rat model of depression. Journal of Neurochemistry. 136(S1): 410.
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Tajiri N, et al. (2014) NSI-189, a novel neurogenic compound, promotes hippocampal neurogenesis and improves cognitive function in mice. CNS Neuroscience & Therapeutics. 20(8): 777–783.
Related Research Compounds
Research Use Disclaimer
Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medical treatment, dietary supplement, or food ingredient, and is strictly prohibited for human or animal consumption. Kimera Chems supplies this research material solely to qualified institutions and professional investigators for authorized laboratory research.
