SLU-PP-332 (ERR Pan-Agonist) Research Standard
SLU-PP-332 is a potent, synthetic small-molecule pan-agonist of the Estrogen-Related Receptors (ERRs), specifically targeting ERR-alpha, ERR-beta, and ERR-gamma. Built on a hydrazone scaffold that links a 4-hydroxybenzohydrazide core to a naphthalene ring system, this compound is a vital tool for studying mitochondrial metabolism and the transcriptional programs associated with oxidative energy expenditure. Often cited in literature as an “exercise mimetic,” SLU-PP-332 is employed to isolate and investigate the PGC-1-alpha-linked gene programs that drive mitochondrial biogenesis and fatty-acid oxidation at the nuclear-receptor level.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | SLU-PP-332 |
| CAS Number | 303760-60-3 |
| Chemical Formula | C18H14N2O2 |
| Molecular Weight | 290.32 g/mol |
| Chemical Class | Hydrazone derivative / ERR Pan-agonist |
| Target(s) | ERR-alpha (primary), ERR-beta, ERR-gamma |
| Physical Appearance | Solid |
| Assay Purity | Refer to the batch-specific Certificate of Analysis (COA) supplied for the lot received |
| Solution Base | Liquid: PEG400, DMSO; Aliquot Vial: Propylene Glycol, PEG400, Benzyl Benzoate, Benzyl Alcohol |
Mechanism of Action & Research Context
SLU-PP-332 provides a direct mechanism to modulate the ERR-driven transcriptional machinery, distinguishing its mode of action from upstream energy sensors.
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ERR Isoform Agonism: The compound stabilizes the active conformation of all three ERR isoforms, with the highest relative potency at ERR-alpha (EC50 ≈ 98 nM).
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Transcriptional Regulation: By promoting the recruitment of coactivators to the ERR binding sites, SLU-PP-332 triggers the upregulation of genes involved in mitochondrial biogenesis and fatty-acid oxidation.
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Direct Nuclear Receptor Modulation: Unlike adrenergic agonists or AMPK activators, which modulate mitochondrial activity through indirect signaling cascades, SLU-PP-332 acts directly at the nuclear receptor level to program the metabolic phenotype.
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Selectivity: The compound demonstrates high selectivity for ERRs over classical Estrogen Receptors (ER-alpha/ER-beta) and other related nuclear receptors, making it a reliable tool for isolating ERR-specific biological effects.
Research Applications
SLU-PP-332 is a specialized reagent essential for modern metabolic and biochemical research.
Primary fields of in vitro laboratory investigation include:
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Mitochondrial Biogenesis Research: Studying the molecular pathways that increase mitochondrial density and oxidative capacity.
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Metabolic Signaling: Modeling the transcriptional adaptations of endurance exercise by upregulating PGC-1-alpha-linked gene programs.
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Fatty-Acid Oxidation Studies: Investigating the enzymatic and transcriptional shifts in lipid metabolism within isolated cell lines.
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Nuclear Receptor Profiling: Utilizing the compound to map the interactome of ERR isoforms and their downstream targets in oxidative tissue.
Storage & Handling Guidelines
Store at controlled room temperature. Keep tightly closed. Liquid formats: do not refrigerate or freeze. Cold storage may cause the solution to cloud or precipitate. If this occurs, return to room temperature and mix until clear.
Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.
Related Research Compounds
Further reading: SLU-PP-332 research overview
Research Use Disclaimer
Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medical treatment, dietary supplement, or food ingredient, and is strictly prohibited for human or animal consumption. Kimera Chems supplies this research material solely to qualified institutions and professional investigators for authorized laboratory research.
