Fenbendazole
Fenbendazole is a synthetic small molecule belonging to the benzimidazole chemical class. Structurally composed of a central benzimidazole core substituted with a phenylsulfanyl (phenylthio) group and a methyl carbamate ester, this compound is highly regarded in structural biology and oncology research. Within controlled in vitro laboratory setups, Fenbendazole serves as a high-precision tool compound for investigating microtubule stability, competitive tubulin binding kinetics, and the disruption of mitotic spindle configurations under isolated experimental conditions.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | Fenbendazole |
| CAS Number | 43210-67-9 |
| IUPAC Name | methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate |
| Molecular Formula | C₁₅H₁₃N₃O₂S |
| Molecular Weight | 299.35 g/mol |
| Chemical Class | Benzimidazole Derivative / Carbamate Ester |
| Assay Purity | Refer to the batch-specific Certificate of Analysis (COA) supplied for the lot received |
| Physical Format | White to off-white solid powder |
Research Applications & Mechanism of Interest
The primary focus of Fenbendazole in modern preclinical science centers on its ability to target structural protein assembly without altering baseline nucleic acid configurations.
Primary fields of in vitro and cell-free laboratory investigation include:
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Tubulin Binding Cross-talk: Measuring competitive ligand interactions at the colchicine-binding domain of purified tubulin dimers. The carbamate group forms highly localized hydrogen bonds with specific amino acid residues, stabilizing the target site.
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Microtubule Polymerization Inhibition: Utilizing real-time turbidimetric or fluorescence assays to monitor how the molecule arrests tubulin protofilament elongation, effectively shutting down structural assembly mechanisms.
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Proteasomal and Glycolytic Stress Modeling: Investigating the compound’s secondary capacity to alter glucose uptake kinetics and downregulate GLUT transporters in cell culture profiles, leading to proteasomal stress pathways.
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Co-Crystallography & Docking Validation: Serving as an organic reference ligand in protein X-ray crystallography to align and test computational molecular docking algorithms against real-world physical coordinates.
Storage & Handling Guidelines
Store at controlled room temperature. Keep tightly closed.
Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.
Related Research Compounds
Research Use Only Disclaimer: This product is developed, synthesized, and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug formulation, active pharmaceutical ingredient, or dietary supplement, and is strictly prohibited for human or veterinary consumption. Kimera Chems supplies these compounds solely to accredited institutional laboratories and certified scientific investigators.
