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Calculated reference model · not an experimental or batch-certified structure. All 30 atoms shown.

Model data & sources
  • The PubChem record does not encode ring geometry. The trans-1,4-cyclohexane configuration is applied from the CAS-specific supplier record and checked in the calculated coordinates.
  • Heavy atoms only; hydrogens are omitted from the reference display.
  • Source-defined stereochemistry is checked against the calculated coordinates; no energy-minimum, crystal or solution-structure claim is made.
  • Reference molecular species only; batch identity, purity, counterions and excipients are not certified.
Formula
C22H24Cl2N2O4
Method
RDKit ETKDGv3 / MMFF94s calculated reference conformer
In stock nowBrowse more certificates
Batch
KC-ISB-01
Made
2026-06-22
Reports
1 on file
Everything shipping from this page today came off this batch. The code is printed on your label, and one certificate covers the whole batch.

ISRIB

Nootropics

Published formats

  • Powder 2g
  • Dry-Fill Capsule 60ct/25mg/1.5g
What is the difference between these?
Powder
Raw material as a solid. Nothing added and nothing portioned; the stated weight is what is in the container.
Dry-Fill Capsule
Capsules filled with the weighed solid. The label gives the amount in each capsule and the number in the bottle.
Each label gives the amount per unit and the total, so compare the totals rather than the container size.

Supplementary product details from the published catalog, checked 2026-10-07. These reference details do not establish current availability.

Pricing

Pricing and order placement are reserved for reviewed research accounts. Log in or submit an account application to view current product pricing.

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Technical Specifications

Batch COA Database ↗
CAS Registry Number1597403-47-8
Molecular FormulaC₂₂H₂₄Cl₂N₂O₄
Molecular Weight451.34 g/mol
IUPAC DesignationTrans-N,N′-(Cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide)
Physical FormWhite to off-white crystalline solid
Storage RequirementsRefer to product documentation
Other NamesISRIB, trans-ISRIB, ISRIB (trans-isomer), cis-ISRIB
Capsule Concentration25mg x 60ct
Bulk Powder Quantity2g

Identity fields from the published product record, checked 2026-10-07. Reference information is not a batch identity certificate.

Research Overview

ISRIB (Integrated Stress Response Inhibitor)

ISRIB (Integrated Stress Response Inhibitor) is a synthetic small-molecule compound studied for its potent ability to modulate cellular stress signaling by counteracting the activation of the integrated stress response (ISR). It is widely utilized in laboratory research focused on translational regulation, protein synthesis, and cellular resilience mechanisms under various stress conditions.

Physical & Handling Properties

Property Specification
Physical Appearance White to off-white crystalline solid
Solubility Soluble in DMSO and common organic solvents; poor aqueous solubility

Mechanism of Action & Research Utility

ISRIB functions by enhancing the activity of eukaryotic initiation factor 2B (eIF2B), the guanine nucleotide exchange factor essential for translation initiation. During cellular stress, the phosphorylation of eIF2α typically suppresses eIF2B activity, thereby reducing global protein synthesis. ISRIB restores translational activity by stabilizing eIF2B in an active conformation, even in the presence of eIF2α phosphorylation.

Primary fields of in vitro laboratory investigation include:

  • Integrated Stress Response (ISR) Signaling: Probing the pathways governing cellular responses to stress.

  • Translational Control: Mapping mechanisms of protein synthesis regulation.

  • Proteostasis: Studying cellular adaptation to metabolic and proteotoxic stress.

  • Cognitive Research: Investigating synaptic plasticity and memory pathways in neurobiological models.

Storage & Handling Guidelines

Store at controlled room temperature. Keep tightly closed.

Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.

Related Research Compounds

Analytical Documentation

Purity, identity, and composition vary by manufacturing lot. Kimera Chems does not publish a single fixed purity figure for this item; refer to the batch-specific Certificate of Analysis (COA) issued for the lot received, which reflects third-party analytical testing for that lot. Contact us if a COA for your lot is required.

Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug formulation, therapeutic agent, or diagnostic application, and is strictly prohibited for human or veterinary consumption. All handling, preparation, and experimental use must comply with applicable laws, regulations, and institutional laboratory safety standards.

Certificates of Analysis

Currently shipping from batch KC-ISB-01.

Related products

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Compounds That Survive Scrutiny

Research use only. Not for human or veterinary use.