SANA (MVD1) Research Standard
SANA (MVD1), chemically identified as 5-(2-nitroethenyl)salicylic acid, is a novel nitroalkene derivative of salicylate that serves as a specialized research tool for studying creatine-dependent thermogenesis. Distinct from classical incretin-based metabolic modulators (such as GLP-1 or GIP agonists), SANA (MVD1) is investigated for its capacity to directly influence energy expenditure at the adipocyte level. By upregulating creatine metabolism and promoting futile creatine cycling, it serves as a unique reference compound for exploring UCP1-independent and AMPK-independent thermogenic pathways.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | SANA (MVD1) |
| Chemical Name | 5-(2-Nitroethenyl)salicylic acid |
| Chemical Formula | C₉H₇NO₅ |
| Chemical Class | Nitroalkene / Salicylate derivative |
| Physical Appearance | Off Yellow Powder |
| Assay Purity | Refer to the batch-specific Certificate of Analysis (COA) supplied for the lot received |
Mechanism of Action & Research Context
SANA (MVD1) represents a distinct mechanistic class in metabolic research, focusing on the acceleration of ATP hydrolysis through futile cycles.
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Creatine-Dependent Thermogenesis: The compound is characterized by its ability to upregulate genes associated with creatine metabolism and enhance creatine kinase activity within adipose tissue.
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Thermogenic Pathway: Unlike classical brown adipose thermogenesis, which relies on Uncoupling Protein 1 (UCP1), SANA functions through a UCP1-independent pathway, driving heat output via the hydrolysis of ATP in a futile creatine cycling loop.
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Pathway Independence: Preclinical data suggests the compound operates independently of the canonical AMPK energy-sensor pathway, distinguishing it from pharmaceutical agents that modulate systemic appetite or metabolic signaling sensors.
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Lean Mass Preservation: Research models contrast the metabolic profile of SANA with that of incretin-based agonists, often citing its potential to preserve lean mass during periods of increased energy expenditure.
Research Applications
SANA (MVD1) is an essential reagent for laboratories investigating the nuances of adipose tissue metabolism and bioenergetics.
Primary fields of in vitro laboratory investigation include:
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Creatine-Dependent Thermogenesis: Mapping the specific molecular steps of creatine-driven futile cycling.
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Adipocyte Bioenergetics: Measuring direct energy expenditure and ATP hydrolysis rates in isolated adipose cells.
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Metabolic Comparative Research: Using SANA as a baseline to differentiate outcomes against incretin-class (GLP-1/GIP) compounds.
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Nitroalkene/Salicylate SAR Studies: Investigating the structure-activity relationship of nitroalkene derivatives on metabolic endpoints.
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UCP1-Independent Research: Utilizing the compound as a tool to bypass classical brown fat activation models.
Storage & Handling Guidelines
Store at controlled room temperature. Keep tightly closed.
Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.
Related Research Compounds
Further reading: SANA (MVD1) research overview
Research Use Disclaimer
Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medical treatment, dietary supplement, or food ingredient, and is strictly prohibited for human or animal consumption. Kimera Chems supplies this research material solely to qualified institutions and professional investigators for authorized laboratory research.
