Seltorexant

CAS: 1293281-49-8
Molecular wt: 407.4
Compound class: Octahydropyrrolo[3,4-b]pyrrole amide

Batch 1 of 2: KC-SLX-01
Batch 2 of 2: KC-SLX-02

The forms on this page come off different batches, so more than one code is shipping. Each has its own certificate, and the code printed on your label is the one you have.

Seltorexant

Seltorexant is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms and Conditions prior to ordering.

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What is the difference between these?

Dry-Fill Capsule: Capsules filled with the weighed solid. The label gives the amount in each capsule and the number in the bottle.
Liquid Dropper: The compound already in solution, in a dropper bottle. The label gives the amount per millilitre, the bottle volume and the total.
Powder: Raw material as a solid. Nothing added and nothing portioned; the stated weight is what is in the container.

Each label gives the amount per unit and the total, so compare the totals rather than the container size.

Description

Seltorexant (JNJ-42847922) Research Standard

Seltorexant (JNJ-42847922, MIN-202) is a potent, orally active, and highly selective Orexin-2 Receptor (OX2R) antagonist. By selectively modulating the orexin signaling pathway, which is integral to arousal and the regulation of the sleep–wake cycle, Seltorexant has emerged as a significant reference compound in neurobiological and pharmacological research. In laboratory and analytical settings, it is utilized to probe the kinetics of the Orexin-2 receptor, map receptor-ligand binding interactions, and investigate the physiological implications of OX2R antagonism in experimental models.

Physical & Handling Properties

Property	Specification
Physical Appearance	White to yellow solid powder
Solution Base	PEG400, DMSO

Mechanism of Action & Research Context

Seltorexant is engineered for high-affinity binding to the Orexin-2 receptor. Its structural features—including the specific fluorine atom positioning and the triazole ring system—are critical for its pharmacological profile.

OX2R Selectivity: The compound exhibits high selectivity for the Orexin-2 receptor over the Orexin-1 receptor (OX1R). Researchers use this selectivity to isolate the effects of OX2R antagonism in cell-based assays and radioligand competition studies.
Binding Pocket Interaction: The molecule’s three-dimensional shape enables a precise fit within the OX2R binding pocket. This makes it an ideal probe for studying receptor-ligand kinetics and displacement dynamics using labeled tracers.
Signaling Modulation: By acting as an antagonist, Seltorexant inhibits the downstream signaling pathways associated with orexin-induced arousal, providing a mechanism to study the reduction of wake-promoting neurochemical activity in controlled in vitro models.

Research Applications

Seltorexant is a specialized reagent essential for modern neuropharmacology and receptor research.

Primary fields of in vitro and analytical laboratory investigation include:

Binding Affinity Assays: Measuring K_i values and binding kinetics to establish potency and selectivity profiles against OX2R versus OX1R.
Competition Binding Studies: Utilizing radioligand displacement assays to map the binding footprint within the Orexin-2 receptor.
Protein Binding Analysis: Evaluating the free fraction of the compound in plasma solutions to support pharmacokinetic modeling.
Receptor Mapping: Employing the compound as a structural probe to examine how specific ligand modifications influence receptor affinity.

Storage & Handling Guidelines

Store at controlled room temperature. Keep tightly closed. Liquid formats: do not refrigerate or freeze. Cold storage may cause the solution to cloud or precipitate. If this occurs, return to room temperature and mix until clear.

Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.

Related Research Compounds

Research Use Disclaimer

Research Use Only Disclaimer: This product is labeled and sold “For Research Use Only — NOT FOR HUMAN CONSUMPTION.” It is not a drug, dietary supplement, food, cosmetic, or medical device, and it is not approved by the FDA or any other regulator for human or veterinary use. It is supplied to approved account holders as a research chemical for laboratory use and must be handled in accordance with applicable law.

Compound Class	Octahydropyrrolo[3,4-b]pyrrole amide
CAS Number	1293281-49-8
Other Names	Seltorexant, AIS8N3O50B, Seltorexantum, 2-(4,6-Dimethylpyrimidin-2-yl)-5-((2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)carbonyl)octahydropyrrolo(3,4-C)pyrrole Methanone, ((3aR,6aS)-5-(4,6-dimethyl-2-pyrimidinyl)hexahydropyrrolo(3,4-C)pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)-, rel-
IUPAC Name	[(3aS,6aR)-2-(4,6-dimethylpyrimidin-2-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-[2-fluoro-6-(triazol-2-yl)phenyl]methanone
Molecular Formula	C21H22FN7O
Molecular Weight	407.4
Capsule Concentration	5mg x 60ct
Liquid Concentration And Solution	10mg/ml PEG400, DMSO
Bulk Powder Quantity	1g

Certificates of Analysis

Batch KC-SLX-02

2 reports
Batch KC-SLX-01

3 reports

Currently shipping from batches KC-SLX-01 and KC-SLX-02. The code printed on your label says which one you have.

Research Use Only
All products supplied by Kimera Chems LLC are intended strictly for laboratory research use. They are not drugs, dietary supplements, food, cosmetics, or veterinary products, and are not for human or animal consumption.

Regulatory Status
Kimera Chems LLC is a chemical supplier. Kimera Chems is not a compounding pharmacy or chemical compounding facility as defined under Section 503A of the Federal Food, Drug, and Cosmetic Act, and is not an outsourcing facility as defined under Section 503B of that Act.

Intended Use and Handling
The products we offer are not intended for human use. They are intended for in-vitro and pre-clinical research purposes only. The customer acknowledges that risks exist in the handling, use, and distribution of these products, and certifies that it has the proper equipment, facilities, and personnel to manage those risks, and knowingly accepts them. These chemicals are not intended to be used, and should not be used, in inappropriate applications — including, without limitation, as food additives, drugs, cosmetics, or household chemicals, or in any application outside of in-vitro laboratory research, pre-clinical research, or laboratory chemical synthesis and materials testing.

Customer Responsibility
By purchasing these products, the customer agrees to the above. In the event the customer uses, or causes others to use, these products outside of these restrictions, the customer accepts all risk of doing so, absolves Kimera Chems of any responsibility for such actions, and agrees to indemnify and hold Kimera Chems harmless against any third-party claims arising from them.

Official Website
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Seltorexant

Description