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![Chemical structure representation of Seltorexant, an octahydropyrrolo[3,4-b]pyrrole amide.](https://kimerachems.co/wp-content/uploads/2026/08/seltorexant-kimera-cover.png)
Seltorexant (JNJ-42847922) Research Standard
Seltorexant (JNJ-42847922, MIN-202) is a potent, orally active, and highly selective Orexin-2 Receptor (OX2R) antagonist. By selectively modulating the orexin signaling pathway, which is integral to arousal and the regulation of the sleep–wake cycle, Seltorexant has emerged as a significant reference compound in neurobiological and pharmacological research. In laboratory and analytical settings, it is utilized to probe the kinetics of the Orexin-2 receptor, map receptor-ligand binding interactions, and investigate the physiological implications of OX2R antagonism in experimental models.
Technical Specifications
| Property | Specification |
|---|---|
| Product Name | Seltorexant (JNJ-42847922) |
| CAS Number | 1293281-49-8 |
| Chemical Formula | C₂₁H₂₂FN₇O |
| Molecular Weight | 407.45 g/mol |
| Chemical Class | Selective Orexin-2 Receptor (OX2R) Antagonist |
| Physical Appearance | White to yellow solid powder |
| Assay Purity | Refer to the batch-specific Certificate of Analysis (COA) supplied for the lot received |
| Solution Base | PEG400, DMSO |
Mechanism of Action & Research Context
Seltorexant is engineered for high-affinity binding to the Orexin-2 receptor. Its structural features—including the specific fluorine atom positioning and the triazole ring system—are critical for its pharmacological profile.
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OX2R Selectivity: The compound exhibits high selectivity for the Orexin-2 receptor over the Orexin-1 receptor (OX1R). Researchers use this selectivity to isolate the effects of OX2R antagonism in cell-based assays and radioligand competition studies.
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Binding Pocket Interaction: The molecule’s three-dimensional shape enables a precise fit within the OX2R binding pocket. This makes it an ideal probe for studying receptor-ligand kinetics and displacement dynamics using labeled tracers.
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Signaling Modulation: By acting as an antagonist, Seltorexant inhibits the downstream signaling pathways associated with orexin-induced arousal, providing a mechanism to study the reduction of wake-promoting neurochemical activity in controlled in vitro models.
Research Applications
Seltorexant is a specialized reagent essential for modern neuropharmacology and receptor research.
Primary fields of in vitro and analytical laboratory investigation include:
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Binding Affinity Assays: Measuring Ki values and binding kinetics to establish potency and selectivity profiles against OX2R versus OX1R.
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Competition Binding Studies: Utilizing radioligand displacement assays to map the binding footprint within the Orexin-2 receptor.
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Protein Binding Analysis: Evaluating the free fraction of the compound in plasma solutions to support pharmacokinetic modeling.
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Receptor Mapping: Employing the compound as a structural probe to examine how specific ligand modifications influence receptor affinity.
Storage & Handling Guidelines
Store at controlled room temperature. Keep tightly closed. Liquid formats: do not refrigerate or freeze. Cold storage may cause the solution to cloud or precipitate. If this occurs, return to room temperature and mix until clear.
Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.
Related Research Compounds
Research Use Disclaimer
Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medical treatment, dietary supplement, or food ingredient, and is strictly prohibited for human or animal consumption. Kimera Chems supplies this research material solely to qualified institutions and professional investigators for authorized laboratory research.
