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Calculated reference model · not an experimental or batch-certified structure. Backbone view: 113 of 217 atoms.

Model data & sources
  • Heavy atoms only; hydrogens are omitted from the reference display.
  • Source-defined atom stereochemistry is checked against the calculated coordinates; no energy-minimum or observed-fold claim is made.
  • Reference molecular species only; batch counterions, excipients and material composition are not certified.
  • Force-field relaxation reached its iteration limit. This is a geometry-checked reference, not a proven equilibrated or minimum-energy structure.
Sequence
Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN-OH
Formula
C129H215N33O55
Method
Source-identical PeptideBuilder idealized backbone / MMFF94s calculated reference conformer

Thymosin Alpha-1

Peptides

Published formats

  • Standard Reference Vial

Supplementary product details from the published catalog, checked 2026-10-07. These reference details do not establish current availability.

Pricing

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Technical Specifications

Batch COA Database ↗
CAS Registry Number62304-98-7
Molecular FormulaC₁₂₉H₂₁₅N₃₃O₅₅
Molecular Weight3108.32
IUPAC Designation(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-6-aminohexanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]-6-aminohexanoyl]amino]-4-carboxybutanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-4-carboxybutanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]propanoyl]amino]-5-[[(1S)-3-amino-1-carboxy-3-oxopropyl]amino]-5-oxopentanoic acid
Physical FormRefer to product documentation
Storage RequirementsRefer to product documentation
Other NamesThymalfasin, Zadaxin, Thymosin alpha1, Thymosin alpha 1

Identity fields from the published product record, checked 2026-10-07. Reference information is not a batch identity certificate.

Research Overview

Thymosin Alpha-1 Research Standard

Thymosin alpha 1 (CAS 62304-98-7), also indexed as thymalfasin, is a peptide originally isolated from thymic tissue as the component responsible for restoring immune function in thymectomised mice.[1] It is supplied as a 10 mg lyophilized powder, and ships with one Acetic Acid 0.6%, 10 mL, per five units ordered.

Mechanism of Action & Research Context

Its mechanism is described in the literature as pleiotropic, affecting multiple immune cell subsets rather than acting on one receptor with one output.[1]

  • Toll-like receptors on dendritic cells are the entry point. Tα1 acts through TLRs in both myeloid and plasmacytoid dendritic cells, activating signalling pathways and initiating production of immune-related cytokines. Working through the innate sensor rather than a dedicated receptor is what gives it such a broad downstream footprint.[1]

  • It can activate or inhibit immune responses. This is the point most often lost in summary. By modulating signals delivered through innate immune receptors on dendritic cells, Tα1 shapes adaptive responses via both effector and regulatory T-helper functions — earning the review title “the regulator of regulators”. It is a modulator in the literal sense, not a stimulant, and the direction depends on context.[2]

  • Regulatory T cells are part of the picture. Treg populations are a pivotal mechanism of immunological tolerance, and malfunctioning Treg responses are documented in chronic inflammatory and autoimmune disease. Tα1's ability to reach that compartment is why it is studied as a tolerance modulator rather than only an immune stimulant.[2]

Research Applications

Primary fields of in vitro and preclinical laboratory investigation include:

  • Dendritic cell activation assays across myeloid and plasmacytoid subsets.[1,2]

  • Toll-like receptor signalling studies.[1]

  • T-helper effector and regulatory function assays, designed to detect modulation in either direction.[2]

  • Cytokine production panels in immune cell subsets.[1]

Analytical Documentation

Purity and identity vary by manufacturing lot. Kimera Chems does not publish a single fixed purity figure for this item; refer to the batch-specific Certificate of Analysis (COA) issued for the lot received, which reflects third-party analytical testing for that lot.

References

  1. King R, Tuthill C. Immune modulation with thymosin alpha 1 treatment. Vitam Horm. 2016;102:151–178. doi:10.1016/bs.vh.2016.04.003
  2. Bonifazi P, D'Angelo C, Fallarino F, et al. Thymosin alpha1: the regulator of regulators? Ann N Y Acad Sci. 2010;1194:1–5. doi:10.1111/j.1749-6632.2010.05465.x

Storage & Handling

Store at controlled room temperature, sealed and protected from light.

Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.

Related Research Compounds

Research Use Only Disclaimer: This product is labeled and sold "For Research Use Only - NOT FOR HUMAN CONSUMPTION." It is not a drug, dietary supplement, food, cosmetic, or medical device, and it is not approved by the FDA or any other regulator for human or veterinary use. It is supplied to approved account holders as a research chemical for laboratory use and must be handled in accordance with applicable law.

Certificates of Analysis

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Compounds That Survive Scrutiny

Research use only. Not for human or veterinary use.