Alpha GPC

Alpha-GPC 50%

Identity

Alpha-GPC (L-alpha-glycerylphosphorylcholine) is a naturally occurring choline-containing phospholipid metabolite and a direct biosynthetic precursor to acetylcholine. This preparation is standardized to 50% active Alpha-GPC by weight, adsorbed onto an inert carrier (silica or calcium phosphate) to stabilize the highly hygroscopic active.

Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.

Note on the 50% grade: Pure Alpha-GPC is extremely hygroscopic and difficult to handle as a free-flowing powder. The carrier-adsorbed 50% form improves gravimetric handling and short-term stability for laboratory weighing and solution preparation. For studies requiring the pure compound, pure-grade Alpha-GPC is the appropriate material.

Research applications

• Acetylcholine synthesis pathway studies
• Choline bioavailability and neurotransmitter turnover research
• Cholinergic signaling and neuromuscular assays
• Phospholipid metabolism studies

Quality control

• HPLC for assay and purity
• Loss on drying (LOD) for moisture content
• Identity confirmation against reference standards
• Batch-specific COA

Mechanistic Background

Alpha-GPC is cleaved in tissue to free choline and glycerophosphate, enlarging the precursor pool available for acetylcholine synthesis. Preclinical work has used it to raise brain acetylcholine and to probe cholinergic contributions to memory consolidation, making it a common positive-control precursor in cholinergic pathway experiments.

Selected Research Literature

Peer-reviewed preclinical literature indexed on PubMed, provided for scientific context only. These are animal and in-vitro studies; nothing here describes or implies a use for this material.

• Lopez CM, Govoni S, Battaini F, et al. Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine. Pharmacol Biochem Behav. 1991;39(4):835-840. doi:10.1016/0091-3057(91)90040-9
• Lee SH, Choi BY, Kim JH, et al. Late treatment with choline alfoscerate increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment. Brain Res. 2016;1654(Pt A):66-76. doi:10.1016/j.brainres.2016.10.011

Handling note. Lopez et al. report region-dependent effects in hippocampus and cortex but not striatum, so tissue selection matters when designing acetylcholine measurements.

Related Cholinergic Reference Materials

Other choline-pathway and cholinergic compounds in the Nootropics catalog:

• CDP-Choline (Citicoline) — nucleotide choline donor used in membrane phospholipid synthesis studies
• Coluracetam — high-affinity choline uptake (HACU) enhancer
• Lemairamin (WGX-50) — α7 nicotinic acetylcholine receptor agonist standard

Related Research Compounds

• Coluracetam
• ODY (FCS)
• CDP-Choline (Citicoline)
• Adrafinil

Analytical Documentation

Purity, identity, and composition vary by manufacturing lot. Kimera Chems does not publish a single fixed purity figure for this item; refer to the batch-specific Certificate of Analysis (COA) issued for the lot received, which reflects third-party analytical testing for that lot. Contact us if a COA for your lot is required.

Research Use Disclaimer

Research Use Only Disclaimer: This product is labeled and sold "For Research Use Only - NOT FOR HUMAN CONSUMPTION." It is not a drug, dietary supplement, food, cosmetic, or medical device, and it is not approved by the FDA or any other regulator for human or veterinary use. It is supplied to approved account holders as a research chemical for laboratory use and must be handled in accordance with applicable law.