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Calculated reference model · not an experimental or batch-certified structure. All 29 atoms shown.

Model data & sources
  • Heavy atoms only; hydrogens are omitted from the reference display.
  • Source-defined stereochemistry is checked against the calculated coordinates; no energy-minimum, crystal or solution-structure claim is made.
  • Reference molecular species only; batch identity, purity, counterions and excipients are not certified.
Formula
C26H28ClNO
Method
RDKit ETKDGv3 / MMFF94s calculated reference conformer
In stock nowBrowse more certificates
Batch
KC-ENC-05
Reports
3 on file
Everything shipping from this page today came off this batch. The code is printed on your label, and one certificate covers the whole batch.

Enclomiphene

Estrogen Receptor Modulators

Published formats

  • Dry-Fill Capsule 60ct/6.25mg/375mg
  • Liquid Dropper 30ml/25mg per ml/750mg
  • Powder 1g
  • Dry-Fill Capsule 60ct/12.5mg/750mg
What is the difference between these?
Dry-Fill Capsule
Capsules filled with the weighed solid. The label gives the amount in each capsule and the number in the bottle.
Liquid Dropper
The compound already in solution, in a dropper bottle. The label gives the amount per millilitre, the bottle volume and the total.
Powder
Raw material as a solid. Nothing added and nothing portioned; the stated weight is what is in the container.
Each label gives the amount per unit and the total, so compare the totals rather than the container size.

Supplementary product details from the published catalog, checked 2026-10-07. These reference details do not establish current availability.

Pricing

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Technical Specifications

Batch COA Database ↗
CAS Registry Number15690-57-0
Molecular FormulaC26H28ClNO
Molecular Weight406.0 g/mol
IUPAC Designation2-[4-[(E)-2-chloro-1,2-diphenylethenyl]phenoxy]-N,N-diethylethanamine
Physical FormOff-white to pale crystalline solid
Storage RequirementsRefer to product documentation
Solution VehiclePEG400, DMSO
Other NamesEnclomiphene, Enclomifene, En-Clomiphene, Enclomiphen (E)-2-(p-(2-Chloro-1,2-Diphenylvinyl)phenoxy)triethylamine, trans-Clomiphene
Capsule Concentration6.25mg x 60ct; 12.5mg x 60ct
Liquid Concentration and Solution25mg/ml PEG400, DMSO
Bulk Powder Quantity1g

Identity fields from the published product record, checked 2026-10-07. Reference information is not a batch identity certificate.

Research Overview

Enclomiphene

Enclomiphene is a non-steroidal, synthetic triphenylethylene derivative classified as a selective estrogen receptor modulator (SERM). Structurally, it represents the isolated trans-isomer (E-configuration) of clomiphene citrate, separating it completely from its geometric twin, zuclomiphene (the cis-isomer).

While traditional clomiphene mixtures present a blend of both isomers, investigators study enclomiphene in isolation so that estrogen receptor binding can be measured for one geometric isomer, without the (Z)-isomer present as a second ligand.

Structural Elements to Observe: The molecular architecture of enclomiphene features a signature triphenylethylene backbone substituted with a core chlorine atom and a flexible tertiary amine side chain. It is the rigid stereo-specific E-configuration across the central double bond that governs its specific structural fit within estrogen receptors. This spatial layout governs its binding mode at the estrogen receptor and distinguishes it from the (Z)-isomer in binding assays.

Physical & Handling Properties

Property Specification
Physical Appearance Off-white to pale crystalline solid
Solubility Profile Soluble in organic solvents such as anhydrous ethanol and DMSO
Solution Base PEG400, DMSO

Mechanism of Action & Research Applications

The primary scientific value of enclomiphene is its binding at the estrogen receptor as a single (E)-isomer.

Primary fields of preclinical and in vitro laboratory investigation include:

  • Estrogen Receptor Binding: Competitive binding at ERα and ERβ, with Ki values compared against the (Z)-isomer.

  • Isomer-Resolved Reference Standard: HPLC method development that separates (E)- and (Z)-clomiphene, with the (Z)-isomer quantified as a specified impurity.

  • Comparative SERM SAR: Benchmarking the triphenylethylene scaffold against other SERM chemotypes in receptor binding and reporter assays.

Storage & Handling Guidelines

Store at controlled room temperature. Keep tightly closed. Liquid formats: do not refrigerate or freeze. Cold storage may cause the solution to cloud or precipitate. If this occurs, return to room temperature and mix until clear.

Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.

Related Research Compounds

Further reading: Enclomiphene research overview

Analytical Documentation

Purity, identity, and composition vary by manufacturing lot. Kimera Chems does not publish a single fixed purity figure for this item; refer to the batch-specific Certificate of Analysis (COA) issued for the lot received, which reflects third-party analytical testing for that lot. Contact us if a COA for your lot is required.

Research Use Only Disclaimer: This product is labeled and sold "For Research Use Only — NOT FOR HUMAN CONSUMPTION." It is not a drug, dietary supplement, food, cosmetic, or medical device, and it is not approved by the FDA or any other regulator for human or veterinary use. It is supplied to approved account holders as a research chemical for laboratory use and must be handled in accordance with applicable law.

Certificates of Analysis

Currently shipping from batch KC-ENC-05.

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Research use only. Not for human or veterinary use.