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Y134 Research Standard
Y134 is a synthetic small-molecule selective estrogen receptor modulator (SERM) structurally related to the benzothiophene derivative Raloxifene. Engineered for high selectivity for the estrogen receptor α (ERα) over estrogen receptor β (ERβ), Y134 serves as a precise tool for investigating estrogen signaling, receptor pharmacology, and hormone-dependent cellular pathways. By optimizing the scaffold shared with Raloxifene analogs, Y134 provides enhanced ERα selectivity, allowing researchers to study tissue-specific modulation—acting as an agonist in bone tissue and an antagonist in reproductive tissues—without the broad cross-reactivity often associated with earlier generation SERMs.
Physical & Handling Properties
| Property | Specification |
|---|---|
| Physical Appearance | Yellow to off-white solid |
| Solubility | Soluble in DMSO and ethanol |
| Solution Base | PEG400,DMSO |
Mechanism of Action & Research Context
Y134 is utilized in experimental settings to differentiate between ERα and ERβ signaling pathways, building upon the structural framework of established benzothiophene-class SERMs like Raloxifene.
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ERα Selectivity: While structurally related to Raloxifene, Y134 is optimized to demonstrate marked affinity for ERα relative to ERβ. This selectivity allows investigators to isolate ERα-dependent gene transcription and cellular responses in a controlled laboratory environment.
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Tissue-Specific Modulation: Y134 exhibits dual-action pharmacology; it promotes estrogen-like signaling in bone tissue models while inhibiting estrogen-stimulated cellular proliferation in reproductive tissue models.
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Transcriptional Regulation: The compound modulates estrogen-dependent gene expression, acting as a critical probe for studying hormone-dependent pathway activation and receptor-ligand interactions.
Research Applications
Y134 is a specialized reagent essential for modern endocrinology and oncology research.
Primary fields of in vitro laboratory investigation include:
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Estrogen Receptor Pharmacology: Analyzing the binding affinity and functional modulation of ERα in isolated signaling systems.
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Breast Cancer Proliferation Models: Evaluating the inhibitory effects of Y134 on estrogen-stimulated cellular growth in ER-positive cancer cell lines.
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Bone Density Research: Investigating agonist-like activity in bone tissue and its potential effects on pathways governing bone homeostasis.
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Structure-Activity Relationship (SAR) Studies: Utilizing Y134 as a structural reference to evaluate the efficacy and binding potential of novel SERMs derived from the benzothiophene scaffold.
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Hormone-Dependent Gene Expression: Mapping downstream gene regulatory changes following specific ERα modulation.
Storage & Handling Guidelines
Store at controlled room temperature. Keep tightly closed. Liquid formats: do not refrigerate or freeze. Cold storage may cause the solution to cloud or precipitate. If this occurs, return to room temperature and mix until clear.
Storage guidance is a house recommendation. Analytical documentation is per-lot release testing.
Analytical Documentation
Purity, identity, and composition vary by manufacturing lot. Kimera Chems does not publish a single fixed purity figure for this item; refer to the batch-specific Certificate of Analysis (COA) issued for the lot received, which reflects third-party analytical testing for that lot. Contact us if a COA for your lot is required.
Related Research Compounds
Further reading: Y134 research overview
Research Use Disclaimer
Research Use Only Disclaimer: This product is labeled and sold “For Research Use Only – NOT FOR HUMAN CONSUMPTION.” It is not a drug, dietary supplement, food, cosmetic, or medical device, and it is not approved by the FDA or any other regulator for human or veterinary use. It is supplied to approved account holders as a research chemical for laboratory use and must be handled in accordance with applicable law.
